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TranscriptomicsTranscription profiling of human embryonic kidney cells expressing apoptosis inducing proteins, time series
Three apoptosis inducing proteins, ACO1, STK3 and XBP1 were discovered in a previous reverse transfection screen. HEK293T cells were harvested and RNA extracted from the cells after over-expression of these 3 proteins at 12, 24 and 48 hours. A positive apoptosis inducer staurosporine and a negative ...
ORGANISM(S): Homo sapiens 
2005-09-05 | E-MEXP-421 | biostudies-arrayexpress
ModelsApoptosis Network
To understand the design principles of the molecular interaction network associated with the irreversibility of cell apoptosis and the stability of cell surviving, we constructed a Boolean network integrating both the intrinsic and extrinsic pro-apoptotic pathways with pro-survival signal transducti...
2329 | Cell Collective
ProteomicsFemale mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema
Paladin (Pald1, mKIAA1274 or x99384) was identified in screens for vascular-specific genes and is a putative phosphatase. We have demonstrated that paladin has a predominant vascular expression pattern and shifts from endothelial to mural cells during mouse development. We have now characterized the...
ORGANISM(S): Mus Musculus (mouse) 
2017-11-01 | PXD005625 | JPOST Repository
MetabolomicsMetabolomics identifies the intersection of phosphoethanolamine with menaquinone- triggered apoptosis in an in vitro model of leukemia
Altered metabolism is increasingly acknowledged as an important aspect of cancer, and thus serves as a potentially fertile area for the identification of therapeutic targets or leads. Our recent work using transcriptional data to predict metabolite levels in cancer cells led to preliminary evidence ...
2015-10-19 | MTBLS226 | MetaboLights
TranscriptomicsVitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis
Hippocampal apoptosis is a characteristic feature of penumococcal meningitis associated with learning and memory deficitis as a sequel of the disease. We investigated the effect of vitamin B6 using an established infant rat model of experimental pneumococcal meningitis by histomorphology, transcript...
ORGANISM(S): Rattus norvegicus 
2012-02-20 | E-MEXP-3555 | biostudies-arrayexpress
ProteomicsSo_Kinase_Networks_in_TRAIL_induced_apoptosis
This submission consists of the mass spectrometry raw files for the manuscript by So et al. (Kinase Networks in TRAIL induced apoptosis). This submission contains files for the data presented as supplementary tables 5 (interaction network of 104 protein kinases in DLD-1 cells) acquired on a QSTAR E...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-01-09 | MSV000078989 | MassIVE
TranscriptomicsTranscription profiling of human U937 leukemia cells in apoptosis induced by ansimycin
Anisomycin is known as a potent apoptosis inducer by activating JNK/SAPK and inhibiting protein synthesis during translation. However, only few details are known on the mechanism of apoptosis induced by this compound. Genes in apoptosis induced by anisomycin in human leukemia U937 cells were investi...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8229 | biostudies-arrayexpress
ProteomicsHuman AML secretome and exosomes and correlation with Anti-Apoptotic Index, part 3
Expression of proteins regulating apoptosis (BCL-2, MCL-1, BCL-X and BAX) in acute myeloid leukemia (AML) blasts at diagnosis have been shown to be associated with disease-free survival. We previously found that the initially high apoptosis-resistance of AML cells decreased after therapy, while rega...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080268 | MassIVE
TranscriptomicsNon-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2
A synthetic analog of sphingosine named FTY720 (Fingolimod), phosphorylated by sphingosine kinase-2, interacts with sphingosine-1-phosphate (S1P) receptors expressed on various cells. FTY720 suppresses the disease activity of multiple sclerosis (MS) chiefly by inhibiting S1P-dependent egress of auto...
ORGANISM(S): Homo sapiens 
2011-04-16 | E-GEOD-28642 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed genes in H2AX knockdown cells undergoing apoptosis
H2AX has been characterized as a novel tumor suppressor protein. Difficiency of H2AX will result in apoptotic inhibition of cancer cells. However, how H2AX epigenetically regulates apoptosis of cancer cells is still unclear. To reveal the genes expression regulated by H2AX and involved in apoptosis,...
ORGANISM(S): Homo sapiens 
2013-01-16 | E-GEOD-43498 | biostudies-arrayexpress
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