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ProteomicsA dual RNA regulator balancing carbon uptake and 1 central metabolism in Vibrio cholerae
Bacterial small RNAs (sRNAs) are well-known to modulate gene expression by base-pairing with trans-coded transcripts and are typically considered to be non-coding. However, several sRNAs have been reported to also contain an open reading frame and thus are considered dual regulators. In this study,...
ORGANISM(S): Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 
2021-07-22 | PXD025275 | Pride
Vibrio cholerae Dual function rna regulator Small protein 
TranscriptomicsLysine-Specific Demethylase 1 Has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity
Lysine Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4), but has coactivator function on some genes through unclear mechanisms. We show that LSD1, interacting with CoREST, associates with and coactivates androgen recep...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-GEOD-52201 | biostudies-arrayexpress
TranscriptomicsIdentification of a microRNA regulator for axon guidance in the olfactory bulb of adult mice
Using the highly sensitive miRNA array, we screened 40 microRNAs abundant in the olfactory bulb and we explored the functions of these miRNAs in the olfactory bulb by Gene Ontology and Kyoto Encyclopedia of Genes annotation. The enrichment results indicated that these miRNAs mainly participated in t...
ORGANISM(S): Mus musculus 
2014-08-27 | E-GEOD-55463 | biostudies-arrayexpress
TranscriptomicsPRDM14 Ensures a Naïve Pluripotency by a Dual Mechanism Involving Signaling and Epigenetic Pathways in Mouse Embryonic Stem Cells
Mouse embryonic stem cells (mESCs) fluctuate between a naïve inner cell mass (ICM)-like state and a primed epiblast-like state of pluripotency in serum, but are harnessed exclusively in a distinctive, apparently more naïve state of pluripotency (the ground state) with inhibitors for mitogen-activate...
ORGANISM(S): Mus musculus 
2013-01-18 | E-GEOD-42580 | biostudies-arrayexpress
TranscriptomicsIntegral roles for Rev-erb alpha and Rev-erb beta in the circadian clock function [Expression array]
The circadian clock acts at the genomic level to coordinate internal behavioral and physiologic rhythms via the CLOCK-BMAL transcriptional heterodimer. Although the nuclear receptors REV-ERB? and ? have been proposed to contribute to clock function, their precise roles and importance remain unresol...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-34018 | biostudies-arrayexpress
UnknownThe plastid-nucleus located DNA/RNA binding protein WHIRLY1 regulates microRNA-levels during stress in barley (Hordeum vulgare L.).
Not available
S-EPMC6161701 | biostudies-literature
GenomicsDual roles of RNF2 in melanoma progression [ChIP-seq]
Epigenetic regulators have emerged as critical factors governing the biology of cancer. Here, in the context of melanoma, we show that RNF2 is prognostic, exhibiting progression-correlated expression in human melanocytic neoplasms. Through a series of gain of function and loss of function studies, w...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-51929 | biostudies-arrayexpress
TranscriptomicsTCF7 is a key regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line
A critical problem in biology is understanding how cells choose between self-renewal and differentiation. To generate a comprehensive view of the mechanisms controlling early hematopoietic precursor self-renewal and differentiation, we used systems-based approaches and murine EML multipotential hema...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-30068 | biostudies-arrayexpress
UnknownA dual-function RNA balances carbon uptake and central metabolism in Vibrio cholerae.
Not available
S-EPMC8672173 | biostudies-literature
GenomicsH1.4K34ac ChIP-sequencing in MCF-7 cells
The linker histone H1 is a key player in chromatin organization, yet our understanding of the regulation of H1 functions by posttranslational modifications is very limited. We provide here the first functional characterization of H1 acetylation. We show that H1.4K34 acetylation (H1.4K34ac) is mediat...
ORGANISM(S): Homo sapiens 
2012-04-14 | E-GEOD-36367 | biostudies-arrayexpress
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