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TranscriptomicsCampylobacter jejuni Cj1000 regulon
Transcriptional regulation mediates adaptation of pathogens to environmental stimuli and is important for host colonisation. The Campylobacter jejuni genome sequence reveals a surprisingly small set of regulators, mostly of unknown function, suggesting an intricate regulatory network. Interestingly,...
ORGANISM(S): Campylobacter jejuni 
2013-07-03 | E-GEOD-43792 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of mono- and biallelic CEBPA mutations in cytogenetically normal AML
Purpose: CEBPA mutations are found as either biallelic (biCEBPA) or monoallelic (moCEBPA). We set out to explore whether the kind of CEBPA mutation is of prognostic relevance in cytogenetically normal AML (CN-AML). Patients and Methods: 467 homogeneously treated CN-AML patients were subdivided into ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-15210 | biostudies-arrayexpress
TranscriptomicsExpression analysis of genes located in the minimally deleted regions of 13q14 and 11q22-23 in chronic lymphocytic leukemia – unexpected expression pattern of the RHO GTPase activator ARHGAP20
In chronic lymphocytic leukemia (CLL), 13q14 and 11q22-23 deletions are found in 2/3 of the cases. 11q22-23 deletions are associated with poor survival, whereas 13q14 deletions as single abnormality are often found in indolent disease forms. The molecular basis for this difference in prognosis is no...
ORGANISM(S): Homo sapiens 
2011-10-13 | E-GEOD-25571 | biostudies-arrayexpress
TranscriptomicsAn eight-gene expression signature for the prediction of survival and time to treatment in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a common and heterogeneous disease. An accurate prediction of outcome is highly relevant for the development of personalized treatment strategies. Microarray technology was shown to be a useful tool for the development of prognostic gene expression scores. Howev...
ORGANISM(S): Homo sapiens 
2011-10-13 | E-GEOD-22762 | biostudies-arrayexpress
TranscriptomicsPrognostic gene signature for AML
Acute myeloid leukemia (AML) is a heterogeneous disease in respect of molecular aberrations and prognosis. We used gene expression profiling of 562 patients treated in the German AMLCG 1999 trial to develop a gene signature that predicts survival in AML. Analysis of 562 samples (140 HGU-133plus2; 42...
ORGANISM(S): Homo sapiens 
2013-02-07 | E-GEOD-37642 | biostudies-arrayexpress
TranscriptomicsExpression data of chronic lymphocytic leukemia patient samples from the REACH study
We assessed genome-wide expression of available pretreatment specimens from CLL patients enrolled in REACH, a study of fludarabine and cyclophosphamide FC or R-FC (addition of rituximab to FC) in relapsed CLL, to understand the disease heterogeneity and explore genes that may be prognostic or predic...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-58211 | biostudies-arrayexpress
TranscriptomicsInactivation of TP53 correlates with disease progression and low miR-34a expression in previously treated chronic lymphocytic leukemia patients
Micro-RNA expression data of CD19 selected B-cells from previously treated and relapsed chronic lymphocytic leukemia patients. We aimed to correlate miR-34a with TP53 mutation status and del17p status. CD19 B-cells from previously treated and relapsed chronic lymphocytic leukemia patients were selec...
ORGANISM(S): Homo sapiens 
2013-03-21 | E-GEOD-45328 | biostudies-arrayexpress
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