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ProteomicsSurfaceome proteomic of glioblastoma revealed potential targets for immunotherapy
Glioblastoma (GBM) is the most common and devastating malignant brain tumor in adults. The mortality rate is very high despite different treatments. New therapeutic targets are therefore highly needed to improve patient care. Cell-surface proteins represent attractive targets due to their accessibil...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD027110 | Pride
Surface proteins Glioblastoma Mutated proteins Surfaceome Immunotherapy 
ProteomicsTherapeutic anti-glioma effect of the combined action of PCSK inhibitor with the anti-tumoral factors secreted by Poly (I:C) - stimulated macrophages
Macrophages plasticity is a key feature in cancer progression. Neoplastic cells can alter their immune functions and orient them into a pro-tumoral phenotype. In this context and based on our previous work, we developed a new therapeutic strategy to switch macrophages phenotype and reactivate their ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-23 | PXD020258 | Pride
Glioma Rat Macrophages Reactivation Proprotein convertases Poly (i:c) 
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