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MetabolomicsComparative label-free lipidomic analysis of Mycobacterium tuberculosis during dormancy and reactivation
Mycobacterium tuberculosis employs several strategies to combat and adapt to adverse conditions encountered inside the host. The non-replicative dormant state of the bacterium is linked to drug resistance and slower response to anti-tubercular therapy. It is known that alterations in lipid content a...
2018-10-22 | MTBLS304 | MetaboLights
MetabolomicsCeramide Promotes Lytic Reactivation of Epstein-Barr Virus in Gastric Carcinoma
Epstein-Barr virus (EBV) has a lifelong latency period after initial infection. Rarely, however, when the EBV immediate early gene BZLF1 is expressed by a specific stimulus, the virus switches to the lytic cycle to produce progeny viruses. We found that EBV infection reduced levels of various cerami...
2023-12-20 | MTBLS7649 | MetaboLights
ProteomicsMycobacterium tuberculosis normoxia hypoxia reactivation with ActivX-desthiobiotin FP probe
Lysates of Mycobacterium tuberculosis (H37Rv auxotroph mc(2)6020) grown under various conditions (normoxia, hypoxia, reactivation from hypoxia) probed the serine hydrolase probe with ActivX-desthiobiotin FP.
ORGANISM(S): Mycobacterium Tuberculosis (ncbitaxon:1773) 
2016-10-10 | MSV000080238 | MassIVE
ProteomicsProtemics of human cell during HHV-6A reactivation
HHV-6A is a human herpesvirus that integrates into human sub telomeric regions to acquire latency. This latent virus frequently reactivates causing numerous diseases. The project was aimed to understand changes in host cell prteomics upon virus reactivation, which might helpin understanding the path...
ORGANISM(S): Homo sapiens (Human) 
2020-04-07 | PXD016211 | Pride
Hhv-6a Viral reactivation 
TranscriptomicsMetSearch: A screening platform for the discovery of genes implicated in metastatic dormancy and reactivation
We have developed a screening platform for the isolation of genetic entities involved in metastatic reactivation. Retroviral libraries encoding cDNAs from highly metastatic breast cancer cells or pooled microRNAs were transduced into breast cancer cells that become dormant upon infiltrating the lung...
ORGANISM(S): Mus musculus 
2015-11-24 | E-GEOD-43483 | biostudies-arrayexpress
ProteomicsProfiling the proteome of Mycobacterium tuberculosis during dormancy and reactivation
Tuberculosis, caused by Mycobacterium tuberculosis, still remains a major global health problem. The main obstacle in eradicating this disease is the ability of this pathogen to remain dormant in macrophages, and to get reactivated later under immuno-compromised conditions. The physiology of hypoxic...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2015-06-01 | PXD001158 | Pride
Lc-msms Mycobacterium tuberculosis Dormancy Reactivation Quantitative proteomics 
TranscriptomicsComparative genomic hybridization of human NA, NP1, NR1, NR15 cells denoting different re-activiations of EBV to investigate the effect of highly recurrent EBV reactivation on genetic copy number alterations
We proposed that the frequency of EBV reactivation may be crucial for its pathogenic role and highly recurrent EBV reactivations exert a profound influence on genome instability. Recurrent reactivations were induced in the EBV-latently infected NPC cells (NA cells) by treating with 12-o-tetradecanoy...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6472 | biostudies-arrayexpress
ProteomicsTemporal Analysis of Cell Protein Ubiquitination during Epstein-Barr Virus Reactivation by BCR Cross-linking
Epstein-Barr virus (EBV) reactivation in latently infected B cells is essential for persistent infection and B cell receptor (BCR) activation is a physiologically relevant stimulus for EBV reactivation. Post-translational modifications, such as phosphorylation and ubiquitination, are known to be reg...
ORGANISM(S): Homo sapiens (Human) 
2017-02-02 | PXD004562 | Pride
Epstein barr virus  ubiquitination  reactivation  silac  proteomics  apoptosis Bcr 
TranscriptomicsNuclesome Distribution data for KSHV reactivation
iSLK.219 cells at 0, 6, 12, 24, and 48 hours post KSHV reactivation. Nucleosome occupancy plays a key role in regulating access to the eukaryotic genomes. Although various chromatin regulatory complexes are known to regulate nucleosome occupancy, the role of DNA sequence in this regulation remains...
ORGANISM(S): Homo sapiens 
2013-11-19 | E-GEOD-52453 | biostudies-arrayexpress
TranscriptomicsGlobal Bidirectional Transcription of the Epstein-Barr Virus Genome During Reactivation
Using strand specific RNA-seq to assess the EBV transcriptome during reactivation of Akata cells, we found extensive bidirectional transcription extending across nearly the entire genome. Illumina strand-specific RNA-seq of BCR-activated Akata cells at 9 time points
ORGANISM(S): Homo sapiens 
2013-12-24 | E-GEOD-52490 | biostudies-arrayexpress
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