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MetabolomicsIntegrated genomic and metabolomic profiling of ISC1, an emerging Leishmania donovani population in the Indian subcontinent

Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in Nepalese hilly districts have increased as well as VL cases cau...

2022-09-15 | MTBLS1606 | MetaboLights
TranscriptomicsTranscription profiling of yeast rho0 cells (complete deletion of the mitochondrial genome), in cells with either a single defective enzyme or several, vs cells after prolonged treatment with the bc1 inhibitors myxothiazol or antimycin to analyse respiratory defects
The mitochondrial respiratory chain is composed of lipoprotein complexes imbedded in the inner mitochondrial membrane. This chain of enzymes transfers electrons from NADH and FADH2, provided from divers metabolic pathways, to oxygen. It couples the transfer of electrons to the translocation of proto...
ORGANISM(S): Saccharomyces cerevisiae 
2009-02-20 | E-MEXP-585 | biostudies-arrayexpress
MetabolomicsFour layer multi-omics reveals molecular responses to aneuploidy in Leishmania

Aneuploidy causes system-wide disruptions in the stochiometric balances of transcripts, proteins, and metabolites, often resulting in detrimental effects for the organism. The protozoan parasite Leishmania has an unusually high tolerance for aneuploidy, but the molecular and functional consequenc...

2022-09-19 | MTBLS1612 | MetaboLights
UnknownToward e-Scales: Digital Administration of the International Parkinson and Movement Disorder Society Rating Scales.
Not available
S-EPMC7853197 | biostudies-literature
UnknownArgonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells.
Not available
S-EPMC4226100 | biostudies-literature
UnknownHighly luminescent scintillating hetero-ligand MOF nanocrystals with engineered Stokes shift for photonic applications.
Not available
S-EPMC9205964 | biostudies-literature
UnknownMicronutrient Status of Critically Ill Patients with COVID-19 Pneumonia.
Not available
S-EPMC10856879 | biostudies-literature
TranscriptomicsArgonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells
The roles of Argonaute proteins in cytoplasmic miRNA and RNAi pathways are well established. However, their implication in small RNA-mediated transcriptional gene silencing in the mammalian cell nucleus is less understood. We have recently shown that intronic siRNAs cause chromatin modifications tha...
ORGANISM(S): Homo sapiens 
2014-09-29 | E-GEOD-56826 | biostudies-arrayexpress
ProteomicsImportance of choroid plexus-mediated extracellular vesicle secretion in the pathogenesis of Alzheimer’s disease
Alzheimer’s disease (AD) is a major neurodegenerative disease characterized by extracellular amyloid β (Aβ) plaques and intracellular hyperphosphorylated tau (P-tau). Increasing evidence indicates that extracellular vesicles (EVs) play an important role in AD pathogenesis. We previously reported tha...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD021665 | Pride
Ev Choroid plexus Csf Alzheimer Aβo 
UnknownGrass Snakes (Natrix natrix) as a Reservoir of Alaria alata and Other Parasites.
Not available
S-EPMC8878953 | biostudies-literature
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