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TranscriptomicsAstrocyte elevated gene-1 (AEG-1) and c-Myc cooperate to promote hepatocarcinogenesis
Double transgenic mice with hepatocyte-specific expression of AEG-1 and c-Myc show aggressive HCC compared to single transgenics. Gene expression was analyzed to understand the molecular mechanism by which AEG-1 and c-Myc cooperate to promote hepatocarcinogenesis. Livers were collected from naïve ad...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-61875 | biostudies-arrayexpress
TranscriptomicsA novel 3-D organotypic culture model by co-culturing alpha-SMA positive CAF and cholangiocarcinoma cells in a collagen matrix
The increased M-NM-1-smooth muscle-actin positive cancer-associated fibroblastic cells (CAF) in the desmoplastic stroma may relate to a more aggressive cancer and worse survival outcomes for intrahepatic cholangiocarcinoma (ICC) patients We developed a novel 3-D organotypic culture model by co-cultu...
ORGANISM(S): Rattus norvegicus 
2012-06-22 | E-GEOD-38889 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression profiling of cultured neu-transformed versus spontaneously-transformed rat cholangiocytes and of corresponding cholangiocarcinomas
Characterization of preclinical models of intrahepatic cholangiocarcinoma progression that reliably recapitulate altered molecular features of the human disease. Here, we performed comprehensive gene expression profiling of cholangiocarcinoma tumors arising from bile duct inoculation of different gr...
ORGANISM(S): Rattus norvegicus 
2012-06-20 | E-GEOD-38834 | biostudies-arrayexpress
TranscriptomicsAnalysis of global changes in gene expression induced by human polynucleotide phosphorylase (hPNPaseold-35)
Human Polynucleotide Phosphorylase (hPNPaseold-35) is an evolutionarily conserved 3’?5’ exoribonuclease implicated in the regulation of numerous physiological processes like maintenance of mitochondrial homeostasis, mtRNA import and aging-associated inflammation. From an RNase perspective, little is...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-53604 | biostudies-arrayexpress
TranscriptomicsHIF- and non-HIF-Regulated Hypoxic Responses Require the Estrogen-Related Receptor in Drosophila
Low-oxygen tolerance is supported by an adaptive response that includes a coordinate shift in metabolism and the activation of a transcriptional program that is driven by the hypoxia-inducible factor (HIF) pathway. The precise contribution of HIF-1 in the adaptive response, however, has not been det...
ORGANISM(S): Drosophila melanogaster 
2013-02-05 | E-GEOD-33100 | biostudies-arrayexpress
TranscriptomicsOncogenic Functions of the Transcription Factor LSF
Overexpression of LSF in less aggressive hepatocellular carcinoma (HCC) cells resulted in highly aggressive, angiogenic and multi-organ metastatic tumors while inhibition of LSF significantly abrogated growth and metastasis of highly aggressive HCC cells in nude mice. We used microarrays to identify...
ORGANISM(S): Homo sapiens 
2010-04-06 | E-GEOD-19815 | biostudies-arrayexpress
TranscriptomicsGene expression in the right ventricle of Rattus norvegicus during development of right ventricular heart failure and treatment
Right ventricular heart failure (RVF) associated with pulmonary hypertension (PH) is characterized by a distinct gene expression pattern when compared with functional compensatory hypertrophy. Carvedilol treatment after RVF has been established reduces right ventricle (RV) hypertrophy and improves...
ORGANISM(S): Rattus norvegicus 
2013-05-06 | E-GEOD-42579 | biostudies-arrayexpress
UnknownRab1b overexpression modifies Golgi size and gene expression in HeLa cells and modulates the thyrotrophin response in thyroid cells in culture.
Not available
S-EPMC3583665 | biostudies-literature
UnknownInterlaboratory performance of a microarray-based gene expression test to determine tissue of origin in poorly differentiated and undifferentiated cancers.
Not available
S-EPMC2175545 | biostudies-literature
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