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MetabolomicsThe telomere-to-telomere (T2T) genome of Peucedanum praeruptorum Dunn provides insights into the genome evolution and coumarin biosynthesis

BACKGROUND: Traditional Chinese medicine has used Peucedanum praeruptorum Dunn (Apiaceae) for a long time. Various coumarins, including the significant root constituents Praeruptorin (A-E), are the active constituents of the dried roots of P. praeruptorum. Previous trans...

2024-04-02 | MTBLS8679 | MetaboLights
TranscriptomicsA High-Fat Diet and NAD+ Rescue Premature Aging in Cockayne Syndrome
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in the genes encoding the DNA repair proteins CSA or CSB. Csbm/m mice were given a high-fat, caloric-restricted or resveratrol-supplemented diet. The high-fat diet rescued the p...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-62194 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomics profiling reveals exercise intensity-dependent alterations in Thoroughbred racehorses’ plasma after routine conditioning sessions

Thoroughbred (TB) racehorses are subjected to rigorous conditioning programs involving exercise sessions of various types, distances and intensities. These programs aim to optimize both their physical and mental capabilities, which are essential to achieve maximal performance. Conventional invest...

2024-01-16 | MTBLS8285 | MetaboLights
TranscriptomicsThe transcriptome of Aedes aegypti females from two strains (Chetumal and Rex-D Puerto Rico) either kept on a sugar diet or blood fed
Strain variation in Aedes aegypti transcriptome We report RNA-seq analyses of transcriptional changes across two Ae. aegypti strains
ORGANISM(S): Aedes aegypti 
2011-11-21 | E-GEOD-32074 | biostudies-arrayexpress
TranscriptomicsKaryotyping of maltose-fermenting Saccharomyces yeasts with differing maltotriose utilization profiles
Aims: We performed an analysis of maltotriose utilization by 52 Saccharomyces yeast strains able to ferment maltose efficiently and correlated the observed phenotypes with differences in the copy number of genes possibly involved in maltotriose utilization by yeast cells. Methods and Results: The an...
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-22 | E-GEOD-23055 | biostudies-arrayexpress
GenomicsDistinct p53 Genomic Binding Patterns in Normal and Cancer-derived Human Cells
We report here genome-wide analysis of the tumor suppressor p53 binding sites in normal human cells. 743 high-confidence ChIP-seq peaks representing putative genomic binding sites were identified in normal IMR90 fibroblasts using a reference chromatin sample. More than 40 % were located within 2 kb ...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-31558 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C. elegans sma-9 and dbl-1 gene knock-outs
Experiments performed to determine target genes of sma-9 and DBL-1 signaling
ORGANISM(S): Caenorhabditis elegans 
2022-11-22 | E-MEXP-687 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of self-renewing human pancreatic progenitors derived from pluripotent stem cells
Human pluripotent stem cells were differentiated into PDX1+/NKX6-1+ Pancreatic Progenitors (PPd15 cells), which were subsequently captured and expanded in culture. These culture Pancreatic Progenitors (cPP cells) were capable of self-renewal and could be passaged up to 20 times. Furthermore, cPP cel...
ORGANISM(S): Homo sapiens 
2017-06-06 | E-MTAB-5731 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA and B cell receptor profiling of B cell response to SARS-CoV-2 vaccination
We generated single-cell transcriptomic and BCR sequencing data of B cells from peripheral blood samples taken from a SARS-CoV-2-antigen-naive cohort being vaccinated with the SARS-CoV-2 mRNA-1273 vaccine. Blood samples were collected at the baseline timepoint D-1 (i.e. one day prior to the initial ...
ORGANISM(S): Homo sapiens 
2026-05-08 | E-MTAB-16531 | biostudies-arrayexpress
UnknownStructural and functional basis of protein phosphatase 5 substrate specificity.
Not available
S-EPMC4987771 | biostudies-literature
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