Distinct p53 Genomic Binding Patterns in Normal and Cancer-derived Human Cells

ABSTRACT: We report here genome-wide analysis of the tumor suppressor p53 binding sites in normal human cells. 743 high-confidence ChIP-seq peaks representing putative genomic binding sites were identified in normal IMR90 fibroblasts using a reference chromatin sample. More than 40 % were located within 2 kb of a transcription start site (TSS), a distribution similar to that documented for individually studied functional p53 binding sites and to date not observed by previous genome-wide studies. Nearly half of the high-confidence binding sites in the IMR90 cells reside in CpG islands, in marked contrast to sites reported in cancer-derived cells. The distinct genomic features of the IMR90 binding sites do not reflect a distinct preference for specific sequences, since the de novo developed p53 motif

ORGANISM(S): Homo sapiens

SUBMITTER: Krassimira Botcheva 

PROVIDER: E-GEOD-31558 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress