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ProteomicsCotL, a new morphogenetic coat protein of Clostridium difficile
The strict anaerobe Clostridium difficile is an important nosocomial enteropathogen that has become the most common cause of antibiotic-associated diarrhea. The oxygen-resistant C. difficile spores play a central role in the infectious cycle, contributing to transmission, infection and recurrence. T...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2019-10-16 | PXD010359 | Pride
Spore coat Shotgun proteomics Q exactive hf Clostridium difficile 
ProteomicsThe role of the Ser/Thr kinase PrkC of Clostridium difficile in cell wall homeostasis and antimicrobial resistance.
Clostridium difficile is the leading cause of antibiotic associated diarrhea in adults. During infection, the bacteria must rapidly respond and adapt to the host environment by being able to activate survival strategies. Ser/Thr kinases (STKs) are involved in signal transduction and regulate numerou...
ORGANISM(S): Clostridioides difficile 
2019-06-14 | PXD012241 | Pride
Qexactive hf Clostridium difficile Cell wall Shotgun proteomics 
ProteomicsProteomic analysis of chemical and genetic EZH2 inhibition in diffuse intrinsic pontine glioma cell lines
Diffuse Intrinsic Pontine Glioma (DIPG) is a rare and highly aggressive pediatric tumor. The average survival time after diagnosis is less than one year. Currently, there are no effective treatments. Characteristic of DIPG is a mutation in histone H3 which leads to a substitution of Lysine 27 to Met...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD017525 | Pride
Ezh2 inhibition Quantitative proteome Gsk126 Diffuse intrinsic pontine glioma Ezh2 knock down 
UnknownBacteroides thetaiotaomicron uses a widespread extracellular DNase to promote bile-dependent biofilm formation.
Not available
S-EPMC8851478 | biostudies-literature
ProteomicsProteomic response of diffuse midline glioma to HDAC inhibition reveals adjuvant anti-EBP50 therapy as novel therapeutic concept.
Diffuse midline glioma (DMG) is an aggressive pediatric tumor localized in the brainstem. The median survival after diagnosis is less than one year. Surgical resection is not possible due to the critical localization of the tumor and radiation therapy alone or in combination with chemotherapy show o...
ORGANISM(S): Homo sapiens (Human) 
2021-06-10 | PXD009666 | Pride
Label-free quantitative proteome analysis. Ebp50 Ezrin-radixin-moesin binding protein 50 Diffuse midline glioma Dmg Hdac inhibition 
UnknownThe key sigma factor of transition phase, SigH, controls sporulation, metabolism, and virulence factor expression in Clostridium difficile.
Not available
S-EPMC3133256 | biostudies-literature
UnknownMetabolic adaption to extracellular pyruvate triggers biofilm formation in Clostridioides difficile.
Not available
S-EPMC8630010 | biostudies-literature
UnknownControl of Clostridium difficile Physiopathology in Response to Cysteine Availability.
Not available
S-EPMC4962627 | biostudies-literature
UnknownA microbiota-generated bile salt induces biofilm formation in Clostridium difficile.
Not available
S-EPMC6509328 | biostudies-literature
UnknownA Recombination Directionality Factor Controls the Cell Type-Specific Activation of σK and the Fidelity of Spore Development in Clostridium difficile.
Not available
S-EPMC5025042 | biostudies-literature
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