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ProteomicsHEK293 cells LC-MSMS - XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death
The iTRAQ 4-plex experiment was carried out with 2 biological replicates of untreated HEK cells (114 and 116 label) and 2 biological replicates of HEK cells treated with geneticin (16 µM) for 32 h (115 and 117 label).
ORGANISM(S): Homo sapiens (Human) 
2015-08-10 | PXD000933 | Pride
Human Lc-msms Aminoglycosides Hek293 
MetabolomicsRibosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis

Translation fidelity is the limiting factor in the accuracy of gene expression. With an estimated frequency of 10-4, errors in mRNA decoding occur in a mostly stochastic manner. Little is known about the response of higher eukaryotes to chronic loss of ribosomal accuracy as per an increase in the...

2019-09-17 | MTBLS106 | MetaboLights
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