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ProteomicsSpatial characterization and stratification of colorectal adenomas by Deep Visual Proteomics
Background and Aims: Colorectal adenomas (CRAs) are precursor lesions that can progress to adenocarcinomas. Current clinical guidelines categorize patients into risk groups based on adenoma characteristics observed during index colonoscopy, but this may lead to overtreatment. Our aim was to establis...
ORGANISM(S): Homo sapiens (Human) 
2024-08-04 | PXD046999 | Pride
Spatial Mass spectrometry Pathology Cancer Colorectal adenoma Proteomics Dvp 
ProteomicsSingle-cell-type Spatial Proteomics Unveils Precision Medicine Insights in Composite Small Lymphocytic and Classical Hodgkin Lymphoma
Deep Visual Proteomics (DVP) is an innovative technique that enables spatially resolved sing-cell-type proteome analysis. The coexistence of classical Hodgkin lymphoma (cHL) and small lymphocytic lymphoma (SLL) in a single patient presents a challenging scenario for clinical decision-making. In this...
ORGANISM(S): Homo sapiens (Human) 
2024-10-29 | PXD051795 | Pride
Composite lymphoma  spatial proteomics  mass spectrometry  precision oncology  dvp 
ProteomicsDeep Visual Proteomics reveals DNA replication stress as a hallmark of Signet Ring Cell Carcinoma
Background and Aims: Signet-Ring (SR) cell carcinoma (SRCC) is an increasingly prevalent form of gastric cancer, known for its late presentation and poor treatment outcomes. Using our spatial proteomics pipeline, Deep Visual Proteomics (DVP), we aimed to comprehensively explore the SRCC proteome lan...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053079 | Pride
Deep visual proteomics Signet ring cell carcinoma Precision oncology Spatial proteomics Mass spectrometry Pathology Cancer Case study 
ProteomicsThe proteomic landscape of proteotoxic stress in a fibrogenic liver disease
Protein misfolding diseases, including alpha-1 antitrypsin deficiency (AATD), pose significant health challenges, yet their progression at the cellular level remains poorly understood. Here, we employ spatial proteomics by mass spectrometry and machine learning to map the molecular landscape of AATD...
ORGANISM(S): Homo sapiens (Human) 
2025-02-19 | PXD054440 | Pride
Alpha-1 antitrypsin deficiency Proteotoxic stress Single cell Deep visual proteomics Liver 
ProteomicsDeep Visual Proteomics defines single-cell identity and heterogeneity
Despite the availabilty of imaging-based and mass-spectrometry-based methods for spatial proteomics, a key challenge remains connecting images with single-cell-resolution protein abundance measurements. Here we introduce Deep Visual Proteomics (DVP), which combines artificial-intelligence-driven ima...
ORGANISM(S): Homo sapiens (Human) 
2022-04-27 | PXD023904 | Pride
Microscopy Digital pathology Proteomics Laser microdissection 
TranscriptomicsProgenitor cell combination normalizes retinal vascular development by enhancing pericyte ensheathment in the oxygen-induced retinopathy (OIR) model
Retinopathy of prematurity (ROP) is a disorder of the developing retina of preterm infants. ROP can lead to blindness due to abnormal angiogenesis that is the result of suspended vascular development and vaso-obliteration leading to severe retinal stress and hypoxia. We tested the hypothesis that a ...
ORGANISM(S): Mus musculus 
2019-12-31 | GSE135844 | GEO
UnknownAssociation between amniotic fluid evaluation and fetal biometry: a prospective French "Flash" study.
Not available
S-EPMC5935749 | biostudies-literature
UnknownDensity Visualization Pipeline: A Tool for Cellular and Network Density Visualization and Analysis.
Not available
S-EPMC7333680 | biostudies-literature
UnknownVestibular paroxysmia: clinical characteristics and long-term course.
Not available
S-EPMC9618515 | biostudies-literature
UnknownDeep Visual Proteomics defines single-cell identity and heterogeneity.
Not available
S-EPMC9371970 | biostudies-literature
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