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ProteomicsTLR9-activated B cells imprint adoptively transferred CD8+ T cells with potent tumor immunity and persistence
Here we report a new way to reverse the tolerant state of adoptively transferred CD8+ T cells against melanoma through ex vivo expansion with the TLR9 agonist CpG. CpG-generated T cells elicited potent immunity without co-administration of high dose IL-2 or vaccination, which are adjuvants classical...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD022909 | Pride
T cells adoptive cell transfer therapy toll-like receptors melanoma b cells 
TranscriptomicsPeri-alloHCT IL-33 administration expands recipient T regulatory cells that protect mice against acute GvHD
Graft-versus-Host Disease (GvH) is the excessive inflammatory response by mature T cells contained in the graft during bone marrow transplantation. The allogeneic T cells recognize self-antigens as foreign and systemically attack multiple organs mostly with epithelial structures such as the skin, li...
ORGANISM(S): Mus musculus 
2016-06-27 | E-MTAB-4677 | biostudies-arrayexpress
UnknownAdoptive T Cell Therapy with IL-12-Preconditioned Low-Avidity T Cells Prevents Exhaustion and Results in Enhanced T Cell Activation, Enhanced Tumor Clearance, and Decreased Risk for Autoimmunity.
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S-EPMC8293279 | biostudies-literature
UnknownAge-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects.
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S-EPMC2759371 | biostudies-literature
UnknownComparison of standard 1.5 T vs. 3 T optimized protocols in patients treated with glatiramer acetate. A serial MRI pilot study.
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S-EPMC3382749 | biostudies-literature
UnknownCAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies.
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S-EPMC6094980 | biostudies-literature
UnknownAllogeneic hematopoietic stem cell transplantation after mogamulizumab in T-cell lymphoma patients: a retrospective analysis.
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S-EPMC11136860 | biostudies-literature
UnknownNfkbid Overexpression in Nonobese Diabetic Mice Elicits Complete Type 1 Diabetes Resistance in Part Associated with Enhanced Thymic Deletion of Pathogenic CD8 T Cells and Increased Numbers and Activity of Regulatory T Cells.
Not available
S-EPMC9365269 | biostudies-literature
UnknownB cells regulate CD4+ T cell responses to papain following B cell receptor-independent papain uptake.
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S-EPMC4203309 | biostudies-literature
UnknownEnhanced CD4+ and CD8+ T cell infiltrate within convex hull defined pancreatic islet borders as autoimmune diabetes progresses.
Not available
S-EPMC8387412 | biostudies-literature
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