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MetabolomicsATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly

The ATPase Family AAA Domain Containing 3A (ATAD3A), is a mitochondrial inner membrane protein conserved in metazoans. ATAD3A has been associated with several mitochondrial functions, including nucleoid organization, cholesterol metabolism, and mitochondrial translation. To address its primary ro...

2022-01-14 | MTBLS3786 | MetaboLights
GenomicsNOTCH1/RBPJ complexes drive target gene expression through dynamic interactions with super-enhancers
The main oncogenic driver in T-lymphoblastic leukemia (T-LL) is NOTCH1, which activates genes by forming chromatin-associated Notch transcription complexes. Gamma-secretase (GSI) inhibitor treatment prevents NOTCH1 nuclear localization, but most genes with NOTCH1 binding sites are insensitive to GSI...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-51800 | biostudies-arrayexpress
ProteomicsDynamic of chromosome-binding protein complexes to meiotic prophase I of mouse spermatocyte
Meiotic prophase I (MPI) is the most important event in mammalian meiosis. Even though MPI-related gene expression has been extensively investigated, the status of the chromosome binding proteins (CBPs) and the corresponding complexes in this process has been not scrutinized yet. A quantitative prot...
ORGANISM(S): Mus Musculus 
2023-06-08 | PXD035062 |
ModelsDorvash2019 - Dynamic modeling of signal transduction by mTOR complexes in cancer
This model is based on: Dynamic modeling of signal transduction by mTOR complexes in cancer Author: Mohammadreza Dorvash, Mohammad Farahmandnia, Pouria Mosaddeghi, Mitra Farahmandnejad, Hosein Saber, Mohammadhossein Khorraminejad-Shirazi, Amir Azadi, Iman Tavassoly Abstract: Signal integration has...
2024-09-02 | BIOMD0000000822 | BioModels
ProteomicsDynamic maps of protein-protein-metabolite complexes in S. cerevisiae
The project aims to create dynamic maps of protein-protein-metabolite complexes in S. cerevisiae across growth phases using PROMIS (PROtein–Metabolite Interactions using Size separation). It is a biochemical, untargeted, proteome- and metabolome-wide method to study protein-protein and protein–metab...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-25 | PXD026639 | Pride
Protein-metabolite complexes Ligand Protein-protein complexes 
ProteomicsDynamic maps of protein-protein-metabolite complexes of Arabidopsis Thaliana seedlings
The project aimed to create dynamic maps of protein-protein-metabolite complexes of Arabidopsis thaliana seedlings using PROMIS (PROtein–Metabolite Interactions using Size separation). The approach involves using size exclusion chromatography (SEC) to separate complexes, followed by LC-MS-based pro...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-10-14 | PXD026713 | Pride
Protein-metabolite complexes Ligand Protein-protein complexes 
GenomicsThe dynamic interactome and genomic targets of Polycomb complexes during stem cell differentiation
While the core members of the Polycomb family of proteins (PRC2, PRC1, PR-DUB) are well-characterized, little is known about the specific composition of and protein-protein interactions within these complexes in different cell types. We performed quantitative interaction proteomics and cross-linkin...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-74330 | biostudies-arrayexpress
UnknownDetecting temporal protein complexes from dynamic protein-protein interaction networks.
Not available
S-EPMC4288635 | biostudies-literature
UnknownCryo-EM of dynamic protein complexes in eukaryotic DNA replication.
Not available
S-EPMC5192969 | biostudies-literature
GenomicsIdentification of a dynamic core transcriptional network in t(8;21) AML regulating differentiation block and self-renewal [ChIP-Seq]
The leukemogenic fusion protein RUNX1/ETO impairs myeloid differentiation and drives malignant self-renewal. Here we use digital footprinting and ChIP-sequencing to identify the core RUNX1/ETO responsive transcriptional network of t(8;21) cells. We show that the transcriptional programme underlying ...
ORGANISM(S): Homo sapiens 
2014-09-24 | E-GEOD-60130 | biostudies-arrayexpress
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