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ProteomicsPerilipin 2 mediates milk fat globule secretion
Analysis of the milk fat globule membrane proteome from mice with genetic deletion of Perilipin 2 (Plin2/ADRP/ADPH)
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD035020 | Pride
Adrp Perilipin 2 Apocrine secretion Lc ms/ms Proteomics Lactation Lipid droplet Adph Mouse Milk fat globule membrane 
ProteomicsChaperone-mediated autophagy sustains hematopoietic stem cell function
Activation of mostly quiescent hematopoietic stem cells (HSC) is a prerequisite for life-long blood production1, 2. This process requires major molecular adaptations to meet the regulatory and metabolic requirements for cell division3-8. The mechanisms governing cellular reprograming upon stem cell ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-05 | PXD022196 | Pride
Autophagy  chaperones  lipid metabolism  lysosomes  protein degradation  protein quality control  stem cells 
ProteomicsIdentification of novel protein binders of human MIRO2 in prostate cancer
In previous studies, we showed that MIRO2 mRNA is up-regulated in primary cancer versus normal tissues, across multiple tumor types. MIRO2 had been previously studied in the context of non-tumorigenic cells, where it coordinates microtubule- and actin-based mitochondrial movement. However, we showed...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD029490 | Pride
Cancer Protein interaction Mitochondria Signaling 
ProteomicsAlpha-1-antitrypsin binds to the glucocorticoid receptor with anti-inflammatory and anti-mycobacterial significance in macrophages
Alpha-1-antitrypsin (AAT), a serine protease inhibitor produced mainly by the liver, is the third most abundant protein in plasma. Individuals who possess homozygous Z-AAT genotype have severe AAT deficiency and are at risk for early-onset emphysema, bronchiectasis, cirrhosis, panniculitis, and vas...
ORGANISM(S): Homo sapiens (Human) 
2022-08-24 | PXD030989 | Pride
Tuberculosis Alpha-1-antitrypsin Corticosteroids Glucocorticoids Transcriptional activator 
ProteomicsHb Oxidation in stored RBCs and Vesicles
We used a state of the art proteomics workflow, based upon nano-UPLC-MS\MS and advanced database searching to identify oxidative modifications to functional residues of hemoglobin subunit beta . Progressive accumulation of oxidized residues in stored erythrocytes and selective removal in vesicles wa...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080222 | MassIVE
ProteomicsPD-L1 intracellular interactions that necessitate the TSS motif within the cytoplasmic domain
Lymphatic endothelial cells (LEC) comprise lymphatic vessels that guide immune cells to lymph nodes (LN) and form the subcapsular sinus and cortical and medullary lymphatic structures of the LN. During an active immune response the lymphatics remodel to accommodate the influx of immune cells from th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-06-01 | MSV000089579 | MassIVE
OtherQuantification of Extracellular Matrix Proteins from a Rat Lung Scaffold to Provide a Molecular Readout for Tissue Engineering.
Data from ProteomeXchange, PXD ID: PXD001213. File: 20121108_Native_Frac3_Lung01_Run03.mzml. Published as part of . From the Abstract: {{i}} ... To support organ engineering efforts, we developed a targeted proteomics method to extract and quantify extracellular matrix components from tissues. Our ...
ORGANISM(S): Rat 
GPM32310006954 | GPMDB
Resource Reanalysis 
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