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ProteomicsWEHI991 drug target identification by DIA Solvent PISA
Here we demonstrate PfSTART1 engagement by WEHI991 in the P. falciparum proteome using organic solvent-based Proteome Integral Solubility Alteration (Solvent PISA) assay coupled with Data Independent Acquisition Mass Spectrometry (DIA-MS).
ORGANISM(S): Plasmodium (plasmodium) 
2024-05-01 | PXD048262 | JPOST Repository
ProteomicsIntact-cell thermal PISA-MS target-engagement profiling of M5717 in Plasmodium falciparum
Here we demonstrate eEF1-alpha and eEF2 stabilisation by M5717 in the intact-cell P. falciparum-infected red blood cells, using thermal Proteome Integral Solubility Alteration (Thermal PISA) assay coupled with Data Independent Acquisition Mass Spectrometry (DIA-MS).
ORGANISM(S): Plasmodium (plasmodium) 
2026-02-17 | PXD059612 | JPOST Repository
ProteomicsIdentification of PMV as the target of WEHI-601
Live cell DIA Thermal PISA profiling of WEHI-601 target engagement.
ORGANISM(S): Plasmodium (plasmodium) 
2026-02-14 | PXD069420 | JPOST Repository
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