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ProteomicsLocal translation of mitochondrial proteins at the synapse, LFQ expriment
To systematically explore the dynamics of the synaptic proteome upon neuronal stimulation we employed a simple model system which is based on isolated synaptoeurosomes (SN). Synaptoneurosomes are preparations freshly obtained from the brain and enriched in synapses, containing both pre and postsyna...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-12 | PXD012746 | Pride
Local translation Synaptosomes Quantitative proteomics 
ProteomicsLocal translation of mitochondrial proteins at the synapse
To systematically explore the dynamics of the synaptic proteome upon neuronal stimulation we employed a simple model system which is based on isolated synaptoeurosomes (SN). Synaptoneurosomes are preparations freshly obtained from the brain and enriched in synapses, containing both pre and postsyna...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-12 | PXD012707 | Pride
Local translation Synaptosomes Quantitative proteomics 
ProteomicsMass spectrometry analysis of synaptic proteome of adult Fmr1 KO and wild-type mice.
Fragile X syndrome (FXS) is the most common monogenetic cause of inherited intellectual disability and autism in humans. One of the well-characterized molecular phenotypes of Fmr1 KO mice, a model of FXS, is increased translation of synaptic proteins. Although this upregulation stabilizes in the adu...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD043700 | Pride
Brain Synaptoneurosomes Fmr1 ko mice 
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