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GenomicsTargeting E-prostanoid 3 receptor ameliorates liver fibrosis through enhancing adhesion and cytotoxicity of NK cells toward HSCs
Targeting E-prostanoid 3 receptor ameliorates liver fibrosis through enhancing adhesion and cytotoxicity of NK cells toward HSCs
PRJNA807630 | ENA
UnknownReceptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3.
Not available
S-EPMC5956246 | biostudies-literature
TranscriptomicsTargeting E-prostanoid 3 receptor ameliorates liver fibrosis through enhancing adhesion and cytotoxicity of NK cells toward HSCs
Natural killer (NK) cells exhibit anti-fibrotic properties in liver fibrosis (LF) by suppressing activated hepatic stellate cell (HSC) populations. Prostaglandin (PG) E2 plays a dual role in innate and adaptive immunity. E-prostanoid 3 receptor (EP3) was markedly downregulated in NK cells from liver...
ORGANISM(S): Mus musculus 
2022-02-19 | GSE196864 | GEO
UnknownIncreased role of E prostanoid receptor-3 in prostacyclin-evoked contractile activity of spontaneously hypertensive rat mesenteric resistance arteries.
Not available
S-EPMC5566542 | biostudies-literature
ProteomicsActivation of dimerized BRS3-EP3 suppresses melanoma cell migration through coupling Gαs protein
The mechanism underlying the crosstalk between Gαq-coupled bombesin receptor subtype-3 (BRS3) and Gαi-coupled E-prostanoid 3 receptor (EP3) remains unknown. Here, we report that BRS3 and EP3 form dimers in the membrane of living HEK-293T cells. Interestingly, we found that BRS3-EP3 dimers switched t...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD042449 | Pride
Bombesin receptor subtype-3 E-prostanoid 3 receptor Cell migration Proteomics G-protein-coupled receptors dimerization 
UnknownPhosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression.
Not available
S-EPMC2781639 | biostudies-literature
UnknownCentral EP3 (E Prostanoid 3) Receptors Mediate Salt-Sensitive Hypertension and Immune Activation.
Not available
S-EPMC7040566 | biostudies-literature
UnknownGenetic deletion of the prostaglandin E2 E prostanoid receptor subtype 3 improves anatomical and functional outcomes after intracerebral hemorrhage.
Not available
S-EPMC4696550 | biostudies-literature
UnknownLeukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3.
Not available
S-EPMC5839097 | biostudies-literature
TranscriptomicsProstaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4
Recognition of foreign antigens by B cell receptor (BCR) on mature B cells leads to their clonal expansion, which is critically important for the effective host defence of the organism. However, excessive antigenic responses or reaction of B cells against body’s own components frequently lead to d...
ORGANISM(S): Mus musculus 
2008-12-14 | E-GEOD-9847 | biostudies-arrayexpress
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