Sort   by:  
 Page size 
ProteomicsFunctional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes
Supporting .raw data for "Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes", DOI: 10.15252/embj.2021108823 Related to Figure 1E and EV1A.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-17 | MSV000088403 | MassIVE
ProteomicsInteractome of E1 ubiquitin-activating enzymes and of E2 ubiquitin-conjugating enzymes in human HEK293 cells.
Investigation of E1 ubiquitin-activating enzymes and E2 ubiquitin-conjugating enzymes interactome in human HEK293 cells.
ORGANISM(S): Homo sapiens (Human) 
2023-11-14 | PXD042361 | Pride
E1 ubiquitin-activating enzymes  e2 ubiquitin-conjugating enzymes  ubiquitin  human cells  interactome. 
ProteomicsTargeted protein degradation using E2 ubiquitin-conjugating enzymes
Proteins can be targeted for degradation by using engineered molecular conjugates to enhance their interaction with eukaryotic ubiquitination machinery. For instance, the fusion of an E3 ubiquitin ligase to a suitable target binding domain creates a biological ‘Proteolysis-Targeting Chimera’ (bioPRO...
ORGANISM(S): Homo sapiens (Human) 
2024-09-23 | PXD041225 | Pride
Bioprotac 
TranscriptomicsE2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Ubiquitin and ubiquitin-like proteins (UBLs) are directed to targets by cascades of E1, E2, and E3 enzymes. The largest ubiquitin E3 subclass consists of cullin-RING ligases (CRLs), which contain one each of several cullins (CUL1, -2, -3, -4, or -5) and RING proteins (RBX1 or -2). CRLs are activated...
ORGANISM(S): Mus musculus 
2009-03-23 | E-GEOD-14088 | biostudies-arrayexpress
ProteomicsTomato nuclear proteome reveals the involvement of specific E2 ubiquitin-conjugating enzymes in fruit ripening
Fruits are unique to flowering plants and play a central role in seed maturation and dispersal. Molecular dissection of fruit ripening has received considerable interest because of the biological and dietary significance of fruit. To better understand the regulatory mechanisms underlying fruit ripen...
ORGANISM(S): Solanum lycopersicum 
2014-11-18 | PXD001414 | Pride
Nucleus Fruit ripening Proteomics Tomato Mads-rin Ubiquitination 
ProteomicsProteomic changes induced by knockdown of UBA1 and of E2 ubiquitin-conjugating enzymes in human HEK293 cells (UBE2Q1, UBE2QL1, UBER, UBE2S).Proteomic changes induced by knockdown of UBA1 and of E2 ubiquitin-conjugating enzymes in human HEK293 cells (Ctrl, CtrlHS, E2poolRNAi, E2poolRNAiHS)
The project goal is to identify the proteins that are regulated with loss of the E2 enzymes. In this study E2poolRNAi, E2poolRNAiHS were investigated.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042341 | Pride
Uba1  e2 ubiquitin-conjugating enzymes  ubiquitin  human cells 
UnknownE2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1.
Not available
S-EPMC3941643 | biostudies-literature
ProteomicsProteomic changes induced by knockdown of UBA1 and of E2 ubiquitin-conjugating enzymes in human HEK293 cells (UBE2Q1, UBE2QL1, UBER, UBE2S).Proteomic changes induced by knockdown of UBA1 and of E2 ubiquitin-conjugating enzymes in human HEK293 cells (UBE2Q1, UBE2QL1, UBER, UBE2S)
The project goal is to identify the proteins that are regulated with loss of the E2 enzymes. In this study UBE2Q1, UBE2QL1, UBER, UBE2S were knocked down.
ORGANISM(S): Homo sapiens (Human) 
2023-11-14 | PXD042339 | Pride
Uba1  e2 ubiquitin-conjugating enzymes  ubiquitin  human cells 
ProteomicsProteomic changes induced by knockdown of UBA1 and of E2 ubiquitin-conjugating enzymes in human HEK293 cells (UBE2Q1, UBE2QL1, UBER, UBE2S).Proteomic changes induced by knockdown of UBA1 and of E2 ubiquitin-conjugating enzymes in human HEK293 cells (UBE2T, UBE2V, UBEW, UBE2Z)
The project goal is to identify the proteins that are regulated with loss of the E2 enzymes. In this study UBE2T, UBE2V, UBEW, UBE2Z were knocked down.
ORGANISM(S): Homo sapiens (Human) 
2023-11-14 | PXD042340 | Pride
Uba1  e2 ubiquitin-conjugating enzymes  ubiquitin  human cells 
ProteomicsA prokaryotic E2 enzyme imitates the ubiquitin pathway to regulate the antiviral cGAS
The cyclic oligonucleotide-based anti-phage signalling system (CBASS) is a typeof innate prokaryotic immune system. Composed of a cyclic GMP-AMP synthase (cGAS) and CBASS-associated proteins, CBASS utilizes cyclic oligonucleotides to activate antiviral immunity. One major class of CBASS contains a h...
ORGANISM(S): Serratia Marcescens Lct-sm213 
2024-02-27 | PXD050178 |
Sort   by:  
 Page size