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TranscriptomicsChIP-chip from lymph node-derived primary lymphocytes with anti-E2F2 and anti-SV40TAg
E2F2 is essential for the maintenance of T lymphocyte quiescence. To identify the full set of E2F2 target genes, and to gain further understanding of the role of E2F2 in transcriptional regulation, we have performed ChIP-chip analyses across the genome of lymph node-derived T lymphocytes. Here we sh...
ORGANISM(S): Mus musculus 
2014-01-09 | E-GEOD-53888 | biostudies-arrayexpress
ProteomicsAnalysis of E2F2 interacting proteins
In an attempt to identify proteins interacting with transcription factor E2F2, proteins extracted from HA-E2F2 overexpressing HEK293T cells were were subjected to immunoprecipitation (IP) with an anti-HA antibody or, as a negative control (NegCt), with an anti-T antibody. Immunoprecipitated proteins...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-09 | MSV000079567 | MassIVE
TranscriptomicsTranscription profiling of liver from mouse EF2 mutants vs wild type to investigate the role of E2F2 in liver regeneration
E2F transcription factors are key regulators of cell cycle progression. They are fundamental for crossing the G1/S checkpoint as some of their targets are promoters of essential genes for replication. To analyse the importance of E2F2 in liver regeneration it has been used the well characterised par...
ORGANISM(S): Mus musculus 
2008-10-30 | E-MEXP-1413 | biostudies-arrayexpress
TranscriptomicsExpression data from lenses triply deficient for E2F1, E2F2, and E2F3 transcription factors
The E2F family consists of transcriptional repressors and activators that control cell proliferation. In the classic paradigm of cell cycle regulation, the three activators, E2F1, E2F2 and E2F3, are invariably depicted as the final components of a CDK/Rb signaling cascade that executes the transcrip...
ORGANISM(S): Mus musculus 
2010-06-23 | E-GEOD-16533 | biostudies-arrayexpress
ProteomicsAnalysis of E2F2 interacting proteins
In an attempt to identify proteins interacting with transcription factor E2F2, proteins extracted from HA-E2F2 overexpressing HEK293T cells were were subjected to immunoprecipitation (IP) with an anti-HA antibody or, as a negative control (NegCt), with an anti-T antibody. Immunoprecipitated proteins...
ORGANISM(S): Homo sapiens (Human) 
2013-01-18 | PXD000026 | Pride
E2f2 Immunoprecipitation Lc-ms/ms 
TranscriptomicsIncreased metastasis with loss of E2F2 in Myc-driven tumors
In human breast cancer, mortality is associated with metastasis to distant sites. Therefore, it is critical to elucidate the biological mechanisms that underlie tumor progression and metastasis. Using signaling pathway signatures we previously predicted a role for E2F transcription factors in Myc i...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-71815 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila Myb-MuvB/dREAM
Myb-MuvB (MMB)/dREAM is a nine subunit complex first described in Drosophila as a repressor of transcription, dependent upon E2F2 and the RBFs. Myb, an integral member of MMB, curiously plays no role in the silencing of the test genes previously analyzed. Moreover, Myb plays an activating role in DN...
ORGANISM(S): Drosophila melanogaster 
2008-06-16 | E-GEOD-8751 | biostudies-arrayexpress
TranscriptomicsMMTV-Myc tumor development in E2F-null backgrounds
Advances in genomic signatures have begun to dissect breast cancer heterogeneity, and application of these signatures will allow the prediction of which pathways are important in tumor development. Here we used genomic signatures to predict involvement of specific E2F transcription factors in Myc-i...
ORGANISM(S): Mus musculus 
2011-12-29 | E-GEOD-24594 | biostudies-arrayexpress
TranscriptomicsChromatin immunopreciptiation of human BJ-T cells with E2F2 and EwF4 antibodies
ChIp on chip with E2F2 or E2F4 antibodies on BJ-T cells.
ORGANISM(S): Homo sapiens 
2009-11-16 | E-MEXP-2169 | biostudies-arrayexpress
TranscriptomicsE2f7/E2f8 and E2f1/E2f2/E2f3 null and wild type liver along with E2f7/E2f8 null and wild type trophoblast giant cells
This SuperSeries is composed of the following subset Series: GSE32353: Expression data from E2f7/E2f8 and E2f1/E2f2/E2f3 null and wild type liver along with E2f7/E2f8 null and wild type trophoblast giant cells (nCounter) GSE32354: Expression data from E2f7/E2f8 and E2f1/E2f2/E2f3 null liver (Affym...
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-32355 | biostudies-arrayexpress
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