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TranscriptomicsMerlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus
Current models imply that the FERM domain protein Merlin, encoded by the tumor suppressor NF2, inhibits mitogenic signaling at or near the plasma membrane. Here, we show that the closed, growth inhibitory form of Merlin accumulates in the nucleus, binds to the E3 ubiquitin ligase CRL4DCAF1, and supp...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-19305 | biostudies-arrayexpress
ProteomicsSystemwide disassembly and assembly of SCF ubiquitin ligase complexes
Cells adapt to ever-changing environmental cues by remodeling their inventories of multiprotein complexes. The cellular repertoire of modular multiprotein SCF (SKP1-CUL1-Fbox protein) E3 ligase complexes - which mediate much protein degradation - requires CAND1 to distribute the limiting CUL1 subuni...
ORGANISM(S): Homo sapiens (Human) 
2023-04-14 | PXD038661 | Pride
Crl Ligase Cand1 Scf Formation Assembly Ubiquitin Complex E3 
OtherA systems-wide screen identifies substrates of the SCF-beta-TrCP ubiquitin ligase.
Data from ProteomeXchange, PXD ID: PXD001224. File: OR3_100623_BTrCP_EV_IP_Band01.mzml. Published as part of Sci Signal. 2014 Dec 16;7(356):rs8 . From the Abstract: {{i}} ... We developed a combined bioinformatics and affinity purification-mass spectrometry (AP-MS) workflow for the system-wide iden...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320006530 | GPMDB
Resource Reanalysis 
ProteomicsWnt Regulation: Exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex
Wnt signaling plays key roles in development and disease, by regulating the stability of its key effector βcat. In the absence of Wnt signals, βcat is phosphorylated by the Wnt-regulatory destruction complex, ubiquitinated by an SCF-class E3 ubiquitin ligase, and destroyed by the proteasome. Bindi...
ORGANISM(S): Homo sapiens (Human) 
2020-04-20 | PXD016314 | Pride
Wnt signaling E3 ubiquitin ligase 
TranscriptomicsTumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase
Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1 (HECTH9, ARFBP1, MULE) associates with both MYC and the MYC-associated protein MIZ1. We show here that HUWE1 is required for growth of colorecta...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-59223 | biostudies-arrayexpress
TranscriptomicsExpression Profile Of A Caenorhabditis Elegans Model Of Adult Onset Neuronal Ceroid Lipofuscinosis Reveals Down Regulation Of Ubiquitin E3 Ligase Components.
Transcriptional profiling of two C. elegans mutants of dnj-14, the worm homolog of cysteine string protein (CSP), compared to two control strains N2 (Bristol) and CZ1200. CSP is a neuroprotective protein and the C. elegans mutants, tm3223 and ok237, are used to model the neurodegenerative disease, a...
ORGANISM(S): Caenorhabditis elegans 
2015-12-04 | E-MTAB-3147 | biostudies-arrayexpress
TranscriptomicsSalicylic acid-induced gene expression in wild-type Col-0 and mutant upl3-4 Arabidopsis thaliana plants.
Activation of plant immunity is associated with dramatic transcriptome reprogramming to prioritise immune responses over normal cellular functions. Changes in gene expression are coordinated by the immune hormone salicylic acid (SA). Here we investigated the involvement of the HECT-type ligase Ubiqu...
ORGANISM(S): Arabidopsis thaliana 
2018-11-09 | E-MTAB-7374 | biostudies-arrayexpress
UnknownThe centrosomal E3 ubiquitin ligase FBXO31-SCF regulates neuronal morphogenesis and migration.
Not available
S-EPMC3585373 | biostudies-literature
GenomicsFOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration
FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration
PRJNA1081912 | ENA
TranscriptomicsThe E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity
Analysis of gene expression altered upon knockdown of Siah2 in prosate cancer cells. The objective is to elucidate which signaling pathways or transcription factors are regulated by the E3 ubiquitin ligase Siah2 in human prostate cancer cells. CWR22Rv1 cells were in fected with pLKO.1 control or Sia...
ORGANISM(S): Homo sapiens 
2013-03-19 | E-GEOD-38851 | biostudies-arrayexpress
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