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ProteomicsCentral nervous system involvement of acute lymphoblastic leukemia depends on mRNA translation and complement component 3
Central nervous system (CNS) dissemination of B-precursor acute lymphoblastic leukemia (B-ALL) has a poor prognosis and remains a therapeutic challenge with few recent advances in therapy. Leptomeningeal disease is particularly common in the high risk subgroup of KMT2A-rearranged B-ALL (KMT2A-r B-AL...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD022411 | Pride
Lc-ms Leukemia Lfq 
ProteomicsmiR-126 Governs Human Leukemia Stem Cell Quiescence and Therapeutic Resistance
In acute myeloid leukemia (AML), leukemia stem cells (LSC) play a central role in disease progression and recurrence due to their intrinsic capacity for self-renewal and chemotherapy resistance. Whereas epigenetic mechanisms balance normal blood stem cell self-renewal and fate decisions, mutation an...
ORGANISM(S): Homo sapiens (Human) 
2016-03-31 | PXD001994 | Pride
Aml Global proteomics Scx Stem cells Mir126 
UnknownThe landscape of somatic copy-number alteration across human cancers.
Not available
S-EPMC2826709 | biostudies-literature
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