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TranscriptomicsRNA-seq study of major P.aeruginosa PA14 transcription factors
Gene regulation via transcription factors influences the metabolic, adaptive and pathogenic capabilities of the organism. We report the transcriptomes of the mutants of six major P. aeruginosa PA14 trancription factors - RhlR, LasR, Anr, GacA, FleQ and CbrB. The P. aeruginosa PA14 transposon mutants...
ORGANISM(S): Pseudomonas aeruginosa 
2016-03-01 | E-GEOD-55328 | biostudies-arrayexpress
TranscriptomicsElucidating the Sigmulome of P.aeruginosa PA14 by ChIP-Seq and RNA-Seq approaches
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Pseudomonas aeruginosa 
2015-02-12 | E-GEOD-54999 | biostudies-arrayexpress
GenomicsChIP-seq study of sigma factors in Pseudomonas aeruginosa
Sigma factors are master regulators of bacterial transcription which direct gene expression of specific subsets of genes. In particular, alternative sigma factors are well-known to be key players of bacterial adaptation to changing environments. To elucidate the regulatory network of sigma factors i...
ORGANISM(S): Pseudomonas aeruginosa 
2015-02-12 | E-GEOD-54997 | biostudies-arrayexpress
TranscriptomicsThe P. aeruginosa PA14 transcriptome recorded under 14 different experimental conditions
We analyzed the transcriptional profile of P.aeruginosa PA14 grown under 14 different environmental conditions. These included conditions of growth within biofilms, at various temperatures, osmolarities and phosphate concentrations, under anaerobic conditions, attached to a surface and conditions en...
ORGANISM(S): Pseudomonas aeruginosa 
2015-06-16 | E-GEOD-55197 | biostudies-arrayexpress
TranscriptomicsContribution of Veillonella parvula to Pseudomonas aeruginosa mediated pathogenicity in a murine tumor model system
We investigated the specific interactions of the most dominant bacterial CF-pathogen, Pseudomonas aeruginosa, and the anaerobic bacterium Veilllonella parvula, that has been recovered at comparable cell numbers in the respiratory tract of CF patients. We used our recently established in-vivo murine ...
ORGANISM(S): Veillonella parvula DSM 2008 
2014-11-06 | E-GEOD-58388 | biostudies-arrayexpress
TranscriptomicsAnalysis of sigma factor-dependent gene expression in Pseudomonas aeruginosa by RNA sequencing
Sigma factors are master regulators of bacterial transcription which direct gene expression of specific subsets of genes. In particular, alternative sigma factors are well-known to be key players of bacterial adaptation to changing environments. To elucidate the regulatory network of sigma factors i...
ORGANISM(S): Pseudomonas aeruginosa 
2015-02-12 | E-GEOD-54998 | biostudies-arrayexpress
TranscriptomicsIdentification of the alternative sigma factor SigX regulon and its implications for Pseudomonas aeruginosa pathogenicity
We analyzed a deletion mutant of the ECF M-OM-^C factor SigX and applied mRNA profiling to define the SigX dependent regulon in P. aeruginosa in response to low osmolarity medium conditions. Furthermore, the combination of transcriptional data with chromatin immunoprecipitation (ChIP) followed by hi...
ORGANISM(S): Pseudomonas aeruginosa UCBPP-PA14 
2013-11-11 | E-GEOD-50937 | biostudies-arrayexpress
TranscriptomicsCross-regulation between the response regulators PhoB and TctD allows for the integration of diverse environmental signals in Pseudomonas aeruginosa
Two-component systems (TCS) serve as basic stimulus-response coupling mechanisms to allow organisms to sense and respond to a large variety of environmental conditions. In the opportunistic pathogen Pseudomonas aeruginosa, more than 100 genes encode TCS components. To avoid unwanted cross-talk betwe...
ORGANISM(S): Pseudomonas aeruginosa UCBPP-PA14 
2015-06-08 | E-GEOD-64056 | biostudies-arrayexpress
TranscriptomicsPseudomonas aeruginosa Ceftolozane-Tazobactam Resistance Development Requires Multiple Mutations Leading to Overexpression and Structural Modification of AmpC.
We compared the dynamics and mechanisms of resistance development to ceftazidime, meropenem, ciprofloxacin, and ceftolozane-tazobactam in wild-type (PAO1) and mutator (PAOMS, M-bM-^HM-^FmutS) P. aeruginosa. The strains were incubated for 24 h with 0.5 to 64M-CM-^W MICs of each antibiotic in triplica...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2014-06-12 | E-GEOD-58390 | biostudies-arrayexpress
TranscriptomicsAroA deficient Salmonella Typhimurium – More than an auxotrophic mutant
Recombinant attenuated Salmonella are believed to act as powerful live vaccine carrier able to elicit protection against many infectious agents. ∆aroA exhibits auxotrophy for aromatic amino acids and is commonly used for attenuation. Interestingly, deletion of aroA dramatically increased virulence...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2016-08-09 | E-GEOD-74433 | biostudies-arrayexpress
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