Sort   by:  
 Page size 
ProteomicsExtracellular matrix proteome remodeling with substrate stiffness
Extracellular matrix proteomic profiling Mass spectrometry characterization illustrated a reprogrammed proteome in response to matrix stiffness, including a core subset of 84 ECM-specific proteins, including various ECM regulators and tissue-associated ECM-related proteins. Further, we observe remod...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092971 | MassIVE
GenomicsImpact of ECM Stiffness on Breast Cancer Dormancy in BC-M1 Cells
ECM Stiffness and Breast Cancer Dormancy
PRJEB89749 | ENA
GenomicsImpact of ECM Stiffness on Breast Cancer Dormancy in BC-M1 Cells
ECM Stiffness and Breast Cancer Dormancy
PRJEB89750 | ENA
GenomicsKey role for Rac in the early transcriptional response to ECM stiffness and the stiffness-dependent repression of ATF3
Key role for Rac in the early transcriptional response to ECM stiffness and the stiffness-dependent repression of ATF3
PRJNA989598 | ENA
ProteomicsMatrix stiffness drives alterations in aldehyde metabolism, inducing DNA damage and transformation
Microenvironmental stiffness regulates fundamental aspects of cell behaviour, including proliferation, differentiation and metabolism, many of which are implicated in cancer initiation and progression. In the mammary gland, extracellular matrix (ECM) stiffness, associated with high mammographic dens...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-04 | PXD063452 | Pride
Ecm Mechanosignalling Mammary epithelia 
ProteomicsMatrix Stiffness-Driven Cytoskeletal Remodeling and Tumor Progression in Anaplastic Thyroid Cancer via Integrin-Focal Adhesion Kinase Signaling
Anaplastic thyroid cancer (ATC) is a highly lethal malignancy characterized by rapid progression and therapeutic resistance. This study uncovers the pivotal role of extracellular matrix (ECM) stiffness in driving ATC aggressiveness through mechanotransduction mediated by the Integrin α6β4/Focal Adhe...
ORGANISM(S): Homo Sapiens 
PXD067033 |
ProteomicsRASSF1A controls Tissue Stiffness and Cancer Stem-like Cells in Lung Adenocarcinoma
Lung cancer remains the leading cause of cancer-related death due to poor treatment responses and resistance arising from tumor heterogeneity. Here we show that adverse prognosis associated with epigenetic silencing of the tumour suppressor RASSF1A is due to increased deposition of extracellular mat...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD012694 | Pride
Cancer stem cells Hippo pathway Extracellular matrix. Stiffness 
TranscriptomicsKey role for Rac in the early transcriptional response to ECM stiffness and the stiffness-dependent repression of ATF3
The Rho family GTPases, Rac and Rho, play critical roles in transmitting mechanical information contained within the extracellular matrix (ECM) to the cell. Rac and Rho have well described roles in regulating stiffness-dependent actin remodeling, proliferation and motility. However, much less is kno...
ORGANISM(S): Mus musculus 
2023-10-04 | GSE236266 | GEO
ProteomicsSox9 accelerates vascular ageing by regulating extracellular matrix composition and stiffness
Vascular calcification and increased extracellular matrix (ECM) stiffness are hallmarks of vascular ageing. Sox9 (SRY-Box Transcription Factor 9) is a master regulator of chondrogenesis, also expressed in the vasculature, that has been implicated in vascular smooth muscle cell (VSMC) osteo-chondroge...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD046001 | Pride
Vascular smooth muscle cells Sox9 Extracellular matrix Senescence 
TranscriptomicsExtracellular matrix (ECM) stiffness and collagen-1 (col-1) responsive genes in 3D cultured mammary epithelial cells
We report the expression profiles of MCF10A cells encapsulated in hydrogels of varying stiffness and composition. Cells were encapsulated for 7 days in either 1.) soft alginate and reconstituted basement membrane (rBM), 2.) stiff alginate and rBM, 3,) soft col-1 and rBM, or 4.) stiff col-1. We find ...
ORGANISM(S): Homo sapiens 
2019-03-25 | GSE102506 | GEO
Sort   by:  
 Page size