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TranscriptomicsTranscription profiling of human aortic biopsy samples having differing degrees of stiffness
BACKGROUND: Previous genomic studies with human tissues have compared differential gene expression between 2 conditions (ie, normal versus diseased) to identify altered gene expression in a binary manner; however, a potentially more informative approach is to correlate the levels of gene expression ...
ORGANISM(S): Homo sapiens 
2007-12-13 | E-GEOD-420 | biostudies-arrayexpress
ProteomicsTumor matrix stiffness induces CCN1/CYR61 upregulation of N-Cadherin to promote cancer cell trans-endothelial migration and metastasis
Tumor progression is often accompanied with increased extracellular matrix stiffness, but how this affects endothelial cells (ECs) is largely unknown. We used mass spectrometry to analyse the proteomic changes of primary human ECs cultured on physiological or tumor stiffness and found that CCN1/CYR6...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD003316 | Pride
Stiffness  protome  silac  ccn1  matrigel  huvec  tumour  vasculature 
TranscriptomicsIdentification of candidate genes affecting juvenile wood stiffness in Pinus radiata
Wood stiffness is the most important wood quality trait of forest trees for structural timber production. We investigated genes differentially transcribed in radiate pine trees with distinct wood stiffness using bulked segregant analysis (BSA) and cDNA microarrays. Transcript accumulation in earlywo...
ORGANISM(S): Pinus radiata 
2011-06-01 | E-GEOD-23020 | biostudies-arrayexpress
TranscriptomicsInfluence of substrate stiffness on barrier function in an iPSC-derived in vitro blood-brain barrier model
Induced pluripotent stem cells were differentiated to brain microvascular endothelial-like (BMEC-like) cells and cultured on hydrogel substrates of varying stiffness. Cellular changes were measured by bulk transcriptome and proteome readouts.
ORGANISM(S): Homo sapiens 
2021-04-07 | E-MTAB-10336 | biostudies-arrayexpress
TranscriptomicsFeedback amplication of fibrosis through matrix stiffening and COX-2 suppression
We tested the hypothesis that increasing matrix stiffness on which normal human lung fibroblasts are grown promotes the expression of a fibrogenic cellular transcriptomic program. Keywords: Human lung fibroblast, matrix stiffness, PTGS2, COX-2, Prostaglandin E2 Total RNA extracted from normal human...
ORGANISM(S): Homo sapiens 
2010-07-15 | E-GEOD-22011 | biostudies-arrayexpress
ProteomicsExtracellular matrix proteome remodeling with substrate stiffness
Extracellular matrix proteomic profiling Mass spectrometry characterization illustrated a reprogrammed proteome in response to matrix stiffness, including a core subset of 84 ECM-specific proteins, including various ECM regulators and tissue-associated ECM-related proteins. Further, we observe remod...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092971 | MassIVE
ProteomicsSurface stiffness, hydration, polydimethylsiloxane (PDMS), hyaluronic acid, biofilm and bacterial mobility, protein patterns.
By a global proteomic approach and phenotypic assays, we investigated the impact of surface stiffness on E. coli biofilm formation capacity. A global proteomic approach was used in order to identify the most abundant proteins for the comparison between E. coli adhesion in PDMS 9 kPa and 574kPa, (pol...
ORGANISM(S): Escherichia coli 
2023-03-11 | PXD035233 | Pride
Motion and protein patterns on hyaluronic acid and polydimethylsiloxane depend on surface stiffnes Escherichia coli biofilm formation 
TranscriptomicsRNA-seq of human skin fibroblasts from healthy and systemic sclerosis patients with varying matrix stiffness
This study explores how increased matrix stiffness alters fibroblast transcription and its impact on the lineage specification of fibroblast subpopulations in fibrotic skin. Fibroblasts from healthy and systemic sclerosis patients were cultured in a collagen I-based 3D system with varying matrix sti...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-14804 | biostudies-arrayexpress
ProteomicsmicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis
microRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis
ORGANISM(S): Homo sapiens (Human) 
2019-02-19 | PXD011882 | Pride
Mechanotransduction Mirna Human Homestasis Ago2 Stiffness Huvec 
ProteomicsCellular stiffness sensing through talin 1 in tissue mechanical homeostasis
Tissue mechanical homeostasis, the concept that cells sense mechanical properties and alter rates of ECM synthesis, assembly and degradation, is of broad interest in biology and medicine, but there is little direct support or insight into mechanisms. Tissue mechanical properties such as elasticity a...
ORGANISM(S): Homo sapiens (Human) 
2024-07-16 | PXD041630 | Pride
Focal adhesions Stiffness-sensing Mechanical homeostasis Extra-cellular matrix Talin 
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