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TranscriptomicsRNA-seq of ATDC5 cell-line with scrambled or Sox9 knockdown at 2 hours and 7 days in chondrocgenic differentiation.
Introduction: In addition to the well-known cartilage extracellular matrix-related expression of Sox9, we demonstrated that chondrogenic differentiation of progenitor cells is driven by a sharply defined bi-phasic expression of Sox9: an immediate early and a late (extracellular matrix associated) ph...
ORGANISM(S): Mus musculus 
2021-06-01 | E-MTAB-10333 | biostudies-arrayexpress
TranscriptomicsComparison of Sox9-EGFP cell type transcriptomes during irradiation-induced crypt regeneration
Transcriptional profiling of intestinal epithelial cells expressing either Negative, Sublow, Low or High levels of the Sox9-EGFP reporter transgene FACS-isolated from jejunum of non-irradiated mice or at 5 days after 14Gy abdominal irradiation. 4 distinct cell populations, FACS-isolated based on exp...
ORGANISM(S): Mus musculus 
2012-06-17 | E-GEOD-32227 | biostudies-arrayexpress
TranscriptomicsTestis-to-ovary reprogramming and testis regression after ablation of Sox9 in Sox8-/- mice
We used two Sertoli-cell-specific Cre lines: Wt1-CreERT2 and Sox9-CreERT2, to induce Sox9 ablation on a Sox8 -/- background in the adult testis. Sox9/8 double KO testes undergo testis-to-ovary genetic reprogramming and Sertoli-to-granulosa cell transdifferentiation.
ORGANISM(S): Mus musculus 
2016-06-08 | E-MTAB-4572 | biostudies-arrayexpress
TranscriptomicsSOX9 modulates the expression of key transcription factors required for heart valve development
Heart valve formation initiates when endothelial cells of the heart transform into mesenchyme and populate the cardiac cushions. The transcription factor, SOX9, is highly expressed in the cardiac cushion mesenchyme, and is essential for heart valve development. Loss of Sox9 in mouse cardiac cushion ...
ORGANISM(S): Mus musculus 
2015-11-05 | E-GEOD-73225 | biostudies-arrayexpress
TranscriptomicsExpression profiling of zebrafish sox9 mutants reveals that Sox9 is required for retinal differentiation
The transcription factor gene Sox9 plays various roles in development, including differentiation of the skeleton, testes, glia, and heart. Other functions of Sox9 remain enigmatic. Because Sox9 protein regulates expression of target genes, the identification of Sox9 targets should facilitate an unde...
ORGANISM(S): Danio rerio 
2010-05-16 | E-GEOD-13482 | biostudies-arrayexpress
ProteomicsSox9 accelerates vascular ageing by regulating extracellular matrix composition and stiffness
Vascular calcification and increased extracellular matrix (ECM) stiffness are hallmarks of vascular ageing. Sox9 (SRY-Box Transcription Factor 9) is a master regulator of chondrogenesis, also expressed in the vasculature, that has been implicated in vascular smooth muscle cell (VSMC) osteo-chondroge...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD046001 | Pride
Vascular smooth muscle cells Sox9 Extracellular matrix Senescence 
TranscriptomicsSOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis
Extracellular matrix (ECM) deposition and resultant scar play a major role in the pathogenesis and progression of liver fibrosis. Identifying core regulators of ECM deposition may lead to urgently needed diagnostic and therapetic strategies for the disease. The transcription factor Sex determining r...
ORGANISM(S): Rattus norvegicus 
2019-07-01 | E-MTAB-7298 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of SOX9 over-expressing NT2/D1 cells
To identify novel downstream target genes of SOX9, transcriptome analysis of SOX9 transfected human embryonic testicular cell line, NT2/D1, was carried out.
ORGANISM(S): Homo sapiens 
2015-04-30 | E-MTAB-3378 | biostudies-arrayexpress
TranscriptomicsCharacterization of IGF1 effects on the transcriptome of normal and irradiated Sox9-EGFP cell populations
Transcriptional profiling of intestinal epithelial cells expressing either Negative, Sublow, Low or High levels of the Sox9-EGFP reporter transgene FACS-isolated from jejunum of non-irradiated mice or at 5 days after 14Gy abdominal irradiation. In both groups, mice were treated for 5 consecutive day...
ORGANISM(S): Mus musculus 
2015-04-14 | E-GEOD-42817 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mice mutant for Sox8 and Sox9 has early testicular sterility
To study a possible redundant role of mouse Sox8 and Sox9 after testis induction we generated double mutants by AMH-Cre conditional inactivation of Sox9 in a Sox8-/- background. Double mutants arrest spermatogenesis in early pubescence. We performed expression profiling to explore causes. AMH-Cre/+...
ORGANISM(S): Mus musculus 
2013-01-03 | E-TABM-531 | biostudies-arrayexpress
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