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ProteomicsN-terminomics profiling of naive and inflamed murine colon reveals proteolytic signals of legumain
Legumain is a cysteine protease broadly associated with inflammation. It has recently been reported to cleave and activate protease-activated receptor 2 to provoke pain associated with oral cancer. Outside of gastric and colon cancer, little has been reported on the roles of legumain within the gast...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD051470 | Pride
Protease N-terminomics Legumain Colon Colitis 
ProteomicsFAIMS-enabled N-terminomics analysis reveals novel legumain substrates in murine spleen
Legumain is cysteine protease primarily localised to the endo-lysosomal system. Upregulated legumain activity is associated with inflammation, neurodegeneration, and tumorigenesis. Whilst inhibiting legumain in mouse models has demonstrated therapeutic benefit, the proteolytic mechanisms underpinnin...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD047734 | Pride
Faims Legumain Protease N-terminomics 
ProteomicsFAIMS-enabled N-terminomics analysis reveals novel legumain substrates in murine spleen
Legumain is cysteine protease primarily localised to the endo-lysosomal system. Upregulated legumain activity is associated with inflammation, neurodegeneration, and tumorigenesis. Whilst inhibiting legumain in mouse models has demonstrated therapeutic benefit, the proteolytic mechanisms underpinnin...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD047733 | Pride
Faims Legumain Protease N-terminomics 
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