Sort   by:  
 Page size 
ProteomicsCharacterization of legumain degradation of intact proteins
Legumain or asparagine endopeptidase is a unique cysteine endopeptidase with a distinctive specificity for the hydrolysis of peptide bonds after asparagine and to a lesser extent after aspartate. In order to improve our understanding of legumain substrate recognition we have performed proteomic prof...
ORGANISM(S): Homo sapiens (Human) 
2018-11-29 | PXD010466 | Pride
Degradome Proteases Legumain Cleavage specificity Proteolysis 
ProteomicsFAIMS-enabled N-terminomics analysis reveals novel legumain substrates in murine spleen
Legumain is cysteine protease primarily localised to the endo-lysosomal system. Upregulated legumain activity is associated with inflammation, neurodegeneration, and tumorigenesis. Whilst inhibiting legumain in mouse models has demonstrated therapeutic benefit, the proteolytic mechanisms underpinnin...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD047733 | Pride
Faims Legumain Protease N-terminomics 
ProteomicsArabidopsis thaliana leaf proteome label-free shotgun digested by Legumain at various pH
Proteomic optimisation of Arabidopsis thaliana leaf proteome generated using legumain (cleave C-terminal of asparagine/aspartic acid) as protease at different pH from pH 5.0 to pH 6.5.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-01-20 | PXD014698 | Pride
Arabidopsis legumain digestion 
ProteomicsArabidopsis thaliana proteome label-free shotgun digested by Legumain in the presence of various denaturants
Proteomic optimisation of Arabidopsis thaliana proteome generated using legumain (cleave C-terminal of asparagine/aspartic acid) as protease in the presence of various concentration of denaturants such as acetonitrile, urea, and guanidinium-HCl.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-01-20 | PXD014699 | Pride
Arabidopsis legumain denaturants 
ProteomicsN-terminomics profiling of naive and inflamed murine colon reveals proteolytic signals of legumain
Legumain is a cysteine protease broadly associated with inflammation. It has recently been reported to cleave and activate protease-activated receptor 2 to provoke pain associated with oral cancer. Outside of gastric and colon cancer, little has been reported on the roles of legumain within the gast...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD051470 | Pride
Protease N-terminomics Legumain Colon Colitis 
ProteomicsFAIMS-enabled N-terminomics analysis reveals novel legumain substrates in murine spleen
Legumain is cysteine protease primarily localised to the endo-lysosomal system. Upregulated legumain activity is associated with inflammation, neurodegeneration, and tumorigenesis. Whilst inhibiting legumain in mouse models has demonstrated therapeutic benefit, the proteolytic mechanisms underpinnin...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD047734 | Pride
Faims Legumain Protease N-terminomics 
GenomicsLegumain dependent gene signatures in stromal progenitors
Legumain dependent gene signatures in stromal progenitors
PRJNA800065 | ENA
ProteomicsIdentification of splicing legumain from Momordica cochinchinesis
Analyzse the seed extract of Momordica cochinchinesis displaying legumain activity to identify the coeluted lectin by MALDI-TOF MS/MS
ORGANISM(S): Momordica cochinchinensis 
2022-02-15 | PXD028325 | Pride
Asparginyl endopeptidase Legumain Vacuolar processing enzyme 
ProteomicsIdentification of splicing legumain from Momordica cochinchinesis
Identify the natural legumain McPALs from the seed extract of Momordica cochinchinesis by LC-MS/MS
ORGANISM(S): Momordica cochinchinensis 
2022-02-15 | PXD028327 | Pride
Asparginyl endopeptidase Legumain Vacuolar processing enzyme Mcpal 
ProteomicsArabidopsis thaliana leaf / E.coli / MEF proteomes label-free shotgun
Proteomic comparison of Arabidopsis thaliana leaf / E.coli / MEF proteomes generated by digestion with legumain, GluC and trypsin.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Mus musculus (Mouse) Escherichia coli 
2020-01-20 | PXD014696 | Pride
Arabidopsis thaliana mouse ecoli mef legumain digestion 
Sort   by:  
 Page size