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MetabolomicsImpacts of the Callipyge mutation on ovine plasma metabolites
The ovine Callipyge mutation causes postnatal muscle hypertrophy localized to the pelvic limbs and torso, as well as body leanness. The mechanism underpinning enhanced muscle mass is unclear, as is the systemic impact of the mutation. To investigate potential systemic effects of the mutation, 1H NMR...
2015-01-31 | MTBLS77 | MetaboLights
MetabolomicsPCOS preterm plasma metabolome

This study investigated mid-trimester plasma metabolomic profiles in pregnant women to identify biomarkers associated with Polycystic Ovary Syndrome (PCOS) and preterm birth. A total of 149 participants were categorized into four groups: 32 with PCOS and preterm delivery, 34 with PCOS and term de...

2025-09-09 | MTBLS12968 | MetaboLights
MetabolomicsPregnancy-Induced Metabolic Phenotype Variations in Maternal Plasma
Metabolic variations occur during normal pregnancy to provide the growing fetus with a supply of nutrients required for its development and to ensure the health of the woman during gestation. Mass spectrometry-based metabolomics was employed to study the metabolic phenotype variations in the materna...
2015-03-03 | MTBLS146 | MetaboLights
MetabolomicsMetabolomics profiling of pre-and post-anesthesia plasma samples obtained via Ficoll separation
1H Nuclear Magnetic Resonance (NMR) spectroscopy was used to investigate the metabolic consequences of general anesthesia in the plasma of two groups of patients with diagnosis for non-metastatic colorectal cancer and metastatic colorectal cancer with liver-metastasis, respectively. Patients were tr...
2015-11-17 | MTBLS172 | MetaboLights
MetabolomicsPlasma Lipidomics Identifies Anticedent Memory Impairment in Older Adults
Alzheimer's disease causes a progressive dementia that currently affects over 35 million individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no cures or disease-modifying therapies, and this may be due to our inability to detect the disease before it has progresse...
2014-03-09 | MTBLS72 | MetaboLights
MetabolomicsJ-Resolved 1H NMR 1D-Projections for Large-Scale Metabolic Phenotyping Studies: Application to Blood Plasma Analysis
1H nuclear magnetic resonance (NMR) spectroscopy-based metabolic phenotyping is now widely used for large-scale epidemiological applications. To minimize signal overlap present in 1D 1H NMR spectra, we have investigated the use of 2D J-resolved (JRES) 1H NMR spectroscopy for large-scale phenotyping ...
2018-07-23 | MTBLS540 | MetaboLights
MetabolomicsAn online atlas of human plasma metabolite signatures of gut microbiome composition

Human gut microbiota produce a variety of molecules, some of which enter the bloodstream and impact health. Conversely, dietary or pharmacological compounds may affect the microbiota before entering the circulation. Characterization of these interactions is an important step towards understanding...

2022-05-19 | MTBLS407 | MetaboLights
MetabolomicsMetabolome analysis of plasma from Kmt2c haploinsufficient mice

We aimed to clarify the metabolomic properties of mice with haploinsufficiency in the autism spectrum disorder-related gene lysine methyltransferase 2c (Kmt2c) (Kmt2c+/fs mice). We collected plasma from control (Kmt2c+/+) and Kmt2c+/fs mice, and compared the composition of metabolites using LC-MS...

2026-09-17 | MTBLS15698 | MetaboLights
MetabolomicsPlasma metabolite changes in dairy cows during parturition identified using untargeted metabolomics
The metabolic responses of cows undergo substantial changes during the transition from late pregnancy to early lactation. However, the molecular mechanisms associated with these changes in physiological metabolism have not been clearly elucidated. The objective of this study was to investigate metab...
2019-08-20 | MTBLS809 | MetaboLights
MetabolomicsA red wine intervention does not modify plasma trimethylamine N-oxide but is associated with broad shifts in the plasma metabolome and gut microbiota composition

BACKGROUND: Gut microbiota profiles are closely related to cardiovascular diseases through mechanisms that include the reported deleterious effects of metabolites, such as trimethylamine N-oxide (TMAO), which have been studied as diagnostic and therapeutic targets. Moderate red ...

2024-05-09 | MTBLS310 | MetaboLights
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