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MetabolomicsThe efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting “undruggable” proteins and several PROTACs have reached the stage of clinical candidate...
2025-07-17 | MTBLS11394 | MetaboLights
MetabolomicsHfq Regulates Efflux Pump Expression and Purine Metabolic Pathway to Increase the Trimethoprim Resistance in Aeromonas veronii

Aeromonas veronii (A. veronii) is a zoonotic pathogen. It causes clinically a variety of diseases such as dysentery, bacteremia, and meningitis. And it also brings huge losses to aquaculture. A. veronii has been documented as a multiple antibiotic resistant bacterium. Hfq (host factor for RNA bac...

2020-02-19 | MTBLS1411 | MetaboLights
MetabolomicsMetabolomics analysis reveals the participation of efflux pumps and ornithine in the response of Pseudomonas putida DOT-T1E cells to challenge with propranolol
Efflux pumps are critically important membrane components that play a crucial role in strain tolerance in Pseudomonas putida to antibiotics and aromatic hydrocarbons that result in these toxicants being expelled from the bacteria. Here, the effect of propranolol on P. putida was examined by sudden a...
2016-08-23 | MTBLS320 | MetaboLights
MetabolomicsMolecular basis for multidrug efflux by an anaerobic-associated RND transporter

Bacteria can resist antibiotics and toxic substances within demanding ecological settings, such as low oxygen, extreme acid, and during nutrient starvation. MdtEF, a proton motive force-driven efflux pump from the resistance-nodulation-cell division (RND) superfamily, is upregulated in these cond...

2025-09-26 | MTBLS13050 | MetaboLights
TranscriptomicsBile-induced biofilm formation in Bacteroides thetaiotaomicron requires magnesium efflux by an RND pump
The study is about the role of Bacteroides thetaiotaomicron in the human gut microbiota, specifically its ability to form biofilms in response to bile salts. The study found that bile induces the expression of certain efflux pumps, and inhibiting these pumps impairs biofilm formation. Among the indu...
ORGANISM(S): Bacteroides thetaiotaomicron 
2024-03-19 | E-MTAB-13460 | biostudies-arrayexpress
TranscriptomicsA novel TetR-like transcriptional regulator is induced in acid-nitrosative stress and controls expression of an efflux pump in mycobacteria
Mycobacterium tuberculosis has the ability to survive inside macrophages under acid-nitrosative stress. M. tuberculosis Rv1685c and its orthologue in M. smegmatis, MSMEG_3765, are induced on exposure to acid-nitrosative stress. Both genes are annotated as TetR transcriptional regulators, a family of...
ORGANISM(S): Mycobacterium smegmatis 
2017-10-24 | E-MTAB-5869 | biostudies-arrayexpress
ProteomicsAdaptive β-lactam resistance from an inducible efflux pump that is post-translationally regulated by the DjlA co-chaperone
Interaction between a co chaperone and efflux pump component during induction by antibiotics
ORGANISM(S): Bacteria Caulobacter crescentus (strain NA1000 / CB15N) 
2023-11-09 | PXD040223 | Pride
Caulobacter crescentus chaperone efflux pump 
TranscriptomicsMpeR regulation in Neisseria gonorrhoeae (F19) through an iron-responsive mechanism
Previous studies have shown that the MpeR transcriptional regulator produced by Neisseria gonorrhoeae represses expression of mtrF, which encodes a putative inner membrane protein that works with the MtrC-MtrD-MtrE efflux pump to allow gonococci to resist high levels of multiple hydrophobic antimicr...
ORGANISM(S): Neisseria gonorrhoeae 
2012-04-03 | E-GEOD-32717 | biostudies-arrayexpress
ProteomicsRole of the two-component system CiaRH in the regulation of efflux pump SatAB and its correlation with fluoroquinolones susceptibility
Streptococcus suis is a zoonotic pathogen with a high incidence and mortality rate in both swine and humans. Following antibiotic treatment, the organism has evolved many resistance mechanisms, among of which efflux pump overexpression can promote drug extrusion out of the cell. This study clarified...
ORGANISM(S): Streptococcus suis SC84 
2022-05-24 | PXD033553 | Pride
Two-component systems Efflux pump Repressor Streptococcus suis Fluoroquinolones 
TranscriptomicsDeciphering the role of RND efflux transporters in Burkholderia cenocepacia D4
To compare the expression profile of B. cenocepacia mutants impaired in RND efflux pump encoding genes
ORGANISM(S): Burkholderia cenocepacia 
2011-04-23 | E-MEXP-2999 | biostudies-arrayexpress
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