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ProteomicsHuman EGFR AP-MS project
Mass spectrometry was applied to comprehensively analyze the phosphorylation, ubiquitination, and interactome of wild type and endocytosis-defective EGFR variants before and after internalization in response to EGF or stress.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-23 | MSV000079525 | MassIVE
TranscriptomicsWhole genome expression analysis of a skin biopsy from an individual with multi-organ epithelial inflammation associated with an inherited loss-of-function mutation in EGFR
Whole-genome expression microarray analysis was performed using RNA extracted from skin biopsies sampled from the affected child as well as 4 pooled, healthy controls. The hypothesis was that the downstream effects of the inherited EGFR loss-of-function mutation in the infant would be evident by enr...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-54162 | biostudies-arrayexpress
ProteomicsSoluble SORLA enhances neurite outgrowth and regeneration through activation of EGFR and MAPK pathways
SORLA is a type I transmembrane component associated with Alzheimers disease (AD) risk. Although SORLA is abundantly expressed in neurons, physiological roles for SORLA remain yet unclear. Here, we show that cultured neurons overexpressing SORLA (SORLA TG) feature enhanced neurite length, and accele...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-05-12 | MSV000085400 | MassIVE
ProteomicsProximity biotinylation of Expi293F cells overexpressing EGFR by EGFR-FabID
Expi293F cells were transfected with pcDNA3.1-EGFR and treated with AGIA-FabID or EGFR-FabID in three biological replicates. Cell lysates were subjected to methanol-chloroform precipitation and digested with trypsin. Biotinylated peptides were purified by Tamavidin 2-REV and identified by LC-MS/MS a...
ORGANISM(S): Homo Sapiens (human) 
2023-11-14 | PXD039449 | JPOST Repository
ProteomicsProximity biotinylation of Expi293F cells stably expressing EGFR by EGFR-FabID
Expi293F cells stably expressing EGFR were treated with AGIA-FabID or EGFR-FabID in three biological replicates. Cell lysates were subjected to methanol-chloroform precipitation and digested with trypsin. Biotinylated peptides were purified by Tamavidin 2-REV and identified by LC-MS/MS analysis.
ORGANISM(S): Homo Sapiens (human) 
2023-11-14 | PXD043525 | JPOST Repository
TranscriptomicsUnique microRNA profiles in EGFR-mutated lung adenocarcinomas
We have examined the microRNA expression in 154 lung adenocarcinoma samples and 20 paired normal lung tissue samples and investigated the microRNA expression to clinical variables, EGFR- and KRAS- mutational status and time to progression. 174 samples are analyzed. 154 from lung adenocarcinoma tumor...
ORGANISM(S): Homo sapiens 
2014-03-10 | E-GEOD-48414 | biostudies-arrayexpress
ProteomicsTime-resolved proximity labeling of protein networks associated with ligand-activated EGFR
Ligand binding to the EGF receptor (EGFR) initiates signal transduction and endocytosis of the receptor. The mechanisms of endocytosis and regulation of signaling by endocytosis are poorly understood. Here, we combined peroxidase-catalyzed proximity labeling, isobaric peptide tagging and quantitativ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-04 | PXD030072 | Pride
Proteomics analysis Tmt Endocytosis Tfg Egfr Proximity labeling 
TranscriptomicsMiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer from never-smokers
Approximately 15% of lung cancer cases are not associated with smoking and show molecular and clinical characteristics distinct from those in smokers. Epidermal growth factor receptor (EGFR) gene mutations, which are correlated with sensitivity to EGFR-tyrosine kinase inhibitors (EGFR-TKIs), are mo...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-14936 | biostudies-arrayexpress
OtherProteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.
Data from ProteomeXchange, PXD ID: PXD000788. File: T1041A_Cont3.mzml. Published as part of Mol Cell Proteomics. 2014 Jul;13(7):1644-58 . From the Abstract: {{i}} ass spectrometry was applied to comprehensively analyze the phosphorylation, ubiquitination, and protein-protein interactions of wild ty...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310004705 | GPMDB
Resource Reanalysis 
ProteomicsProximity biotinylation of A431 cells by EGFR-FabID
A431 cells were pretreated with DMSO or gefitinib and unstimulated or stimulated with EGF. Then AGIA-FabID or EGFR-FabID were added to the cells in three biological replicates. Cell lysates were subjected to methanol-chloroform precipitation and digested with trypsin. Biotinylated peptides were puri...
ORGANISM(S): Homo Sapiens (human) 
2023-11-14 | PXD039450 | JPOST Repository
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