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TranscriptomicsExpression data from U87MG cells expressing EGFRvIII
EGFRvIII is the most common deletion mutant of EGFR in human cancer and its levels are highly correlated with poor prognosis in GBM. The deletion of exons 2-7 removes most of the extracellular ligand binding domain, so it is unable to bind EGF or other EGFR-binding ligands. Nevertheless, the mutan...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-36901 | biostudies-arrayexpress
TranscriptomicsExpression data from rat tumors formed by 9L.EV or 9L.EGFRvIII cells
Analysis of rat tumor xenografts revealed genes that are upregulated in tumors expressing EGFRvIII 12 rats received intracranial injections of 9L cells expressing EGFRvIII or an empty vector control. Three weeks after implantation and subsequent growth, tumors were aseptically removed, processed fo...
ORGANISM(S): Rattus norvegicus 
2015-09-08 | E-GEOD-51147 | biostudies-arrayexpress
ProteomicsEGFR and EGFRvIII coopt host defense pathways, promoting progression in glioblastoma
Co-amplification of EGFR and EGFRvIII, a tumor-specific truncation mutant of EGFR, represent hallmark genetic lesions in glioblastoma. We report that EGFR and EGFRvIII stimulate the innate immune defense receptor Toll-like Receptor 2 (TLR2); and that knockdown of TLR2 led to a dramatic survival adva...
ORGANISM(S): Homo sapiens (Human) 
2024-11-26 | PXD034586 | Pride
Cancer Glioblastoma Lfq Phosphorylation 
ProteomicsThe impact of oncogenic EGFRvIII on the proteome of extracellular vesicles (exosomes) released from glioblastoma cells
Glioblastoma multiforme (GBM) is a highly aggressive and heterogeneous form of primary brain tumors, driven by a complex repertoire of oncogenic alterations, including the constitutively active epidermal growth factor receptor (EGFRvIII). EGFRvIII impacts both cell-intrinsic and non-cell autonomous ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-30 | PXD008311 | Pride
Glioblastoma Exosomes Cancer Glioma Extracellular vesicles Heterogeneity Egfrviii Nano-flow cytometry Oncogene Invasion 
GenomicsEGFRvIII/STAT3 targets in glioblastoma pathogenesis
EGFRvIII/STAT3 targets in glioblastoma pathogenesis
PRJNA222297 | ENA
GenomicsRNA-seq Analysis of U87: Ctrl, U87:EGFR, U87:EGFRvIII, U87:EGFR+EGFRvIII and U87:EGFR+EGFRvIII KRAS KO
RNA-seq Analysis of U87: Ctrl, U87:EGFR, U87:EGFRvIII, U87:EGFR+EGFRvIII and U87:EGFR+EGFRvIII KRAS KO
PRJNA483397 | ENA
GenomicsA genome-wide screen identifies E2F6 as critical factor for TMZ chemoresistance in EGFRvIII expressing GBM (EGFRvIII RNA-seq)
A genome-wide screen identifies E2F6 as critical factor for TMZ chemoresistance in EGFRvIII expressing GBM (EGFRvIII RNA-seq)
PRJNA448881 | ENA
TranscriptomicsEGFRvIII vs. Control - xenograft glioblastomas
Glioblastoma cell lines were xenografted onto mice and resulting tumors were profiled by microarray. Xenograft recipient mice were NOD/SCID/gamma (NSG) male mice 3 months old. In this set, 6 total samples were analyzed. There were three biological replicates for each of two conditions: EGFRvIII co...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-46028 | biostudies-arrayexpress
TranscriptomicsEGFRvIII/STAT3 targets in glioblastoma pathogenesis
Next generation sequencing platforms were used to identify STAT3 targets in the background of EGFRvIII expresssion mRNA of 3 EGFRvIII positive brain tumor stem cell lines (BTSC #68, 73, and 90) were compared to an EGFRvIII negative line (#41) to identify EGFRvIII-regulated targets in human BTSC. EGF...
ORGANISM(S): Mus musculus 
2016-04-13 | E-GEOD-51281 | biostudies-arrayexpress
GenomicsExpression data from PDGF-B and EGFRvIII induced murine gliomas
Expression data from PDGF-B and EGFRvIII induced murine gliomas
PRJNA549941 | ENA
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