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ProteomicsProteomic analysis of three Borrelia burgdorferi sensu lato species and disseminating clones: relevance for Lyme vaccine design.
Lyme borreliosis is first characterized by a cutaneous inflammation, the erythema migrans, and if dissemination occurs after an infected tick bite cutaneous, nervous and articular manifestations appear. Although antibiotic treatments are efficient in the early stage of the infection, a significant n...
ORGANISM(S): Borrelia burgdorferi 297 
2015-02-16 | PXD000876 | Pride
Lyme borreliosis / virulence / comparative proteomics / spectral counting 
ProteomicsPhenotypic adaptation of Pseudomonas aeruginosa by hacking siderophores produced by other microorganisms
This study aims at investigating the ability of Pseudomonas aeruginosa to detect the presence of exosiderophores in an epithelial cell infection assay. We show that the presence of exosiderophores induces the transcription and expression of their corresponding transporters, and that bacteria sense t...
ORGANISM(S): Homo sapiens (Human) Pseudomonas aeruginosa PAO1 
2020-02-17 | PXD015638 | Pride
Label-free analysis Pseudomonas aeruginosa Exosiderophores Nanolc-ms/ms 
ProteomicsDiscovery proteomics on cutaneous biopsies
Lyme disease is the most important vector-borne disease in the Northern hemisphere and represents a major public health challenge. The disease diagnosis relies mainly on clinical practice that can be coupled to serological or molecular diagnostics. However the relatively low sensitivity and specific...
ORGANISM(S): Borrelia burgdorferi 297 
2016-07-09 | PXD000879 | Pride
Lyme borreliosis Skin interface Lc-ms/ms 
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