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TranscriptomicsCross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2014-08-18 | E-GEOD-53085 | biostudies-arrayexpress
TranscriptomicsGenome-wide miRNA-expression analysis after p53 activation in colorectal cancer cells
In order to comprehensively identify miRNA-expression changes after p53-activation a miRNA-Seq analysis was conducted after activation of a conditional p53 allele in SW480 cells. SW480/pRTR-p53-VSV cells were subjected to miRNA-Seq analysis after 16 hours doxycycline-treatment. Kompetenzzentrum für ...
ORGANISM(S): Homo sapiens 
2015-07-21 | E-GEOD-67181 | biostudies-arrayexpress
TranscriptomicsExpression data from CD-1 mouse liver samples obtained from in-vivo treatment with genotoxic carcinogens, non-genotoxic carcinogens or non-hepatocarcinogens.
Assessing the carcinogenic potential of drug candidates is a costly procedure which requires the life-long treatment of rodents at different dose levels. A promising approach, which may to a certain degree reduce the need for animal studies in the future is toxicogenomics. The idea is to employ micr...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-44783 | biostudies-arrayexpress
TranscriptomicsCross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat (mRNA)
In this study we performed microarray-based molecular profiling of liver samples from Wistar rats exposed to genotoxic carcinogens (GC), nongenotoxic carcinogens (NGC) or non-hepatocarcinogens (NC) for up to 14 days. In contrast to previous toxicogenomics studies aimed at the inference of molecular ...
ORGANISM(S): Rattus norvegicus 
2014-08-18 | E-GEOD-53082 | biostudies-arrayexpress
Proteomics,Multiomicsp53-regulated networks of protein, mRNA, miRNA and lncRNA expression revealed by integrated pSILAC and NGS analyses
We determined the effect of p53 activation on de novo protein synthesis using quantitative proteomics of newly synthesized proteins (pulsed stable isotope labeling with amino acids in cell culture, pSILAC) in combination with mRNA and non-coding RNA expression analyses by next generation sequencing ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-05-24 | MSV000079767 | MassIVE
TranscriptomicsCross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat (miRNA)
In this study we performed microarray-based molecular profiling of liver samples from Wistar rats exposed to genotoxic carcinogens (GC), nongenotoxic carcinogens (NGC) or non-hepatocarcinogens (NC) for up to 14 days. In contrast to previous toxicogenomics studies aimed at the inference of molecular ...
ORGANISM(S): Rattus norvegicus 
2014-08-18 | E-GEOD-53083 | biostudies-arrayexpress
ProteomicsThe IMiD receptor CRBN determines quality control of transmembrane proteins
The complex architecture of transmembrane proteins requires quality control (QC) for folding and membrane positioning, a prerequisite for cellular homoeostasis and intercellular communication. However, it has remained unclear whether transmembrane proteins-specific QC hubs exist. Here we specify Cer...
ORGANISM(S): Homo sapiens (Human) 
2021-02-18 | PXD018244 | Pride
Imids Chaperones Membrane proteins Lumos Human Multiple myeloma 
UnknownEffect of presurgical aerobic exercise on cardiometabolic health 30 days after bariatric surgery.
Not available
S-EPMC8554771 | biostudies-literature
Proteomicsp53-regulated networks of protein, mRNA, miRNA and lncRNA expression revealed by integrated pSILAC and NGS analyses
We determined the effect of p53 activation on de novo protein synthesis using quantitative proteomics of newly synthesized proteins (pulsed stable isotope labeling with amino acids in cell culture, pSILAC) in combination with mRNA and non-coding RNA expression analyses by next generation sequencing ...
ORGANISM(S): Homo sapiens (Human) 
2015-07-23 | PXD001976 | Pride
Psilac Human Transcriptional network Biomarker P53 Tumor-suppressor 
UnknownMicrocosm enrichment of biphenyl-degrading microbial communities from soils and sediments.
Not available
S-EPMC106808 | biostudies-literature
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