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UnknownConsistent quantitative gene product expression: #1. Automated identification of regenerating bone marrow cell populations using support vector machines.
Identification and quantification of maturing hematopoietic cell populations in flow cytometry data sets is a complex and sometimes irreproducible step in data analysis. Supervised machine learning algorithms present promise to automatically classify cells into populations, reducing subjective bias ...
S-EPMC5132084 | biostudies-literature
UnknownConsistent quantitative gene product expression: #3. Invariance with age.
The quantitative expression of cell surface antigens and light scattering properties of five cellular reference populations in stressed bone marrow specimens were compared between pediatric and adult patients treated for acute myeloid leukemia (AML). The mean intensity of each antigen as well as the...
S-EPMC5132053 | biostudies-literature
UnknownConsistent quantitative gene product expression: #2. Antigen intensities on bone marrow cells are invariant between individuals.
Five reference populations in bone marrow specimens were identified by flow cytometry using specific combinations of reagents in order define the variation of gene product expression intensities both within and between individuals. Mature lymphocytes, uncommitted progenitor cells, promyelocytes, mat...
S-EPMC5132067 | biostudies-literature
UnknownCD33 splicing SNP regulates expression levels of CD33 in normal regenerating monocytes in AML patients.
Not available
S-EPMC7199442 | biostudies-literature
UnknownAcute myeloid leukemia with an MN1-ETV6 fusion in a young child with Down syndrome.
Myeloid leukemia of Down syndrome (ML-DS) in young children is associated with distinct clinical and biological features and is typically initiated with oncogenic mutations in the X-linked megakaryocytic transcription factor GATA1. Here we present a 3-yr-old child with DS diagnosed with acute...
S-EPMC9059786 | biostudies-literature
UnknownCD123 Expression Is Associated With High-Risk Disease Characteristics in Childhood Acute Myeloid Leukemia: A Report From the Children's Oncology Group.

Purpose

Increased CD123 surface expression has been associated with high-risk disease characteristics in adult acute myeloid leukemia (AML), but has not been well-characterized in childhood AML. In this study, we defined CD123 expression and associated clinical characteristics in a uniformly...
S-EPMC8769096 | biostudies-literature
UnknownComprehensive Transcriptome Profiling of Cryptic <i>CBFA2T3-GLIS2</i> Fusion-Positive AML Defines Novel Therapeutic Options: A COG and TARGET Pediatric AML Study.

Purpose

A cryptic inv(16)(p13.3q24.3) encoding the CBFA2T3-GLIS2 fusion is associated with poor outcome in infants with acute megakaryocytic leukemia. We aimed to broaden our understanding of the pathogenesis of this fusion through transcriptome profiling.

Experimental design

A...
S-EPMC7002196 | biostudies-literature
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