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ProteomicseIF1 modulates the recognition of sub-optimal translation start sites and steers gene expression control mediated by uORFs.
Alternative translation initiation mechanisms such as leaky scanning and re-initiation potentiate the polycistronic nature of transcripts. By allowing for reprogrammed translation, these mechanisms can mediate biological responses to stress stimuli. We combined proteomics with ribosome profiling and...
ORGANISM(S): Homo sapiens (Human) 
2017-09-13 | PXD004980 | Pride
Q-exactive hf Alternative translation initiation Human Label-free shotgun proteomics Eif1 Eif1b 
ProteomicsNuclear release of eIF1 globally increases stringency of start codon selection to preserve mitotic arrest physiology
Regulated start codon selection has the potential to reshape the proteome through the differential production of uORFs, canonical proteins, and alternative translational isoforms. However, conditions under which start codon selection is altered remain poorly defined. Here, using transcriptome-wide t...
ORGANISM(S): Homo sapiens (Human) 
2024-10-07 | PXD054183 | Pride
Translation Ribosomes Mitosis Cell cycle 
ProteomicsNuclear release of eIF1 globally increases stringency of start codon selection to preserve mitotic arrest physiology
Regulated start codon selection has the potential to reshape the proteome through the differential production of uORFs, canonical proteins, and alternative translational isoforms. However, conditions under which start codon selection is altered remain poorly defined. Here, using transcriptome-wide t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054179 | Pride
Translation Ribosomes Mitosis Cell cycle 
GenomicsJanthinobacterium lividum strain:EIF1
Janthinobacterium lividum strain:EIF1 Genome sequencing
PRJNA605963 | ENA
GenomicsNuclear release of eIF1 restricts start-codon selection during mitosis
Nuclear release of eIF1 restricts start-codon selection during mitosis
PRJNA957808 | ENA
GenomicseIF1 discriminates against suboptimal initiation sites to prevent excessive uORF translation genome-wide
eIF1 discriminates against suboptimal initiation sites to prevent excessive uORF translation genome-wide
PRJNA576487 | ENA
TranscriptomicseIF1 discriminates against suboptimal initiation sites to prevent excessive uORF translation genome-wide
The translation pre-initiation complex (PIC) scans the mRNA for an AUG codon in favorable context. Previous findings suggest that the factor eIF1 discriminates against non-AUG start codons by impeding full accommodation of Met-tRNAi in the P site of the 40S ribosomal subunit, necessitating eIF1 diss...
ORGANISM(S): Saccharomyces cerevisiae 
2019-10-18 | GSE138599 | GEO
GenomicsEIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy
EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy
PRJNA1475347 | ENA
UnknowneIF1 and eIF5 dynamically control translation start site fidelity.
Not available
S-EPMC12360421 | biostudies-literature
UnknowneIF1 and eIF5 dynamically control translation start site fidelity.
Not available
S-EPMC11257575 | biostudies-literature
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