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TranscriptomicsmRNAs translated at eIF4F
Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray. Although most eukaryotic mRNAs need a functional cap binding complex eIF4F for efficient 5' end-dependent scanning to initiate translation, picornaviral, hepatitis C vi...
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-62 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mRNAs that remained associated with polysomes isolated from human cells after infection with poliovirus
Although most eukaryotic mRNAs need a functional cap binding complex eIF4F for efficient 5' end- dependent scanning to initiate translation, picornaviral, hepatitis C viral, and a few cellular RNAs have been shown to be translated by internal ribosome entry, a mechanism that can operate in the prese...
ORGANISM(S): Homo sapiens 
2005-06-24 | E-SMDB-59 | biostudies-arrayexpress
GenomicseIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations
eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations
PRJNA1142920 | ENA
TranscriptomicsEffect of stress on the binding affinity of yeast eIF4F components to their target RNAs
Translation factors eIF4E and eIF4G form eIF4F, which binds to mRNAs to promote ribosome recruitment and translation initiation. We were interested in analysing the effects of stresses on eIF4F interactions with individual mRNAs. We used a RIP-seq approach to assess how mRNA associations with eIF4E,...
ORGANISM(S): Saccharomyces cerevisiae 
2017-10-11 | E-MTAB-5836 | biostudies-arrayexpress
TranscriptomicsmRNAs translated at eIF4F
Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray. Although most eukaryotic mRNAs need a functional cap binding complex eIF4F for efficient 5' end-dependent scanning to initiate translation, picornaviral, hepatitis C vi...
ORGANISM(S): Homo sapiens 
2002-06-27 | GSE62 | GEO
ProteomicsTwo distinct Trypanosoma eIF4F complexes co-exist, bind different mRNAs and are regulated during nutritional stress
Many eIF4F subunits and PABP paralogues are found in trypanosomes: six eIF4E, five eIF4G, one eIF4A and two PABPs. They are expressed simultaneously and assemble into different complexes, contrasting the situation in metazoans that use distinct complexes in different cell types or developmental stag...
ORGANISM(S): Trypanosoma cruzi Dm28c 
2025-05-06 | PXD051440 | Pride
Nutritional stress Trypanosoma Eif4f Translation initiation 
TranscriptomicseIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations
The eIF4F translation initiation complex plays a critical role in melanoma resistance to clinical BRAF and MEK inhibitors. In this study, we uncover a novel function of eIF4F in the negative regulation of the RAS/RAF/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathway. We demonstrate t...
ORGANISM(S): Homo sapiens 
2024-10-04 | GSE273721 | GEO
GenomicsEffect of stress on the binding affinity of yeast eIF4F components to their target RNAs
Effect of stress on the binding affinity of yeast eIF4F components to their target RNAs
PRJEB21889 | ENA
GenomicsInhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex [A549]
Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex [A549]
PRJNA814884 | ENA
TranscriptomicsScope and mechanism of eIF4F-independent mRNA translation
In eukaryotic cells, protein synthesis typically begins with the binding of eIF4F to the 7-methylguanylate (m7G)cap found on the 5’ end of the majority of mRNAs. Surprisingly, overall translational output remains robust under eIF4F inhibition. The sustained protein synthesis has been largely attribu...
ORGANISM(S): Mus musculus 
2017-07-26 | GSE101865 | GEO
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