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Comparison gene regulation by two different Myc mutants
ORGANISM(S): Mus musculus 
The cell line "6780" derived from murine T-cell lymphoma was grown in RPMI medium 1640 with 10% FBS/1% penicillin/Streptomycin/1% l-glutamine/50 μM 2-mercaptoethanol. Vector constructs containing a dominant negative mutant of the human TGF-beta receptor type II (pMSCV-TGFBR-IRES-GFP) or an empty ve...
ORGANISM(S): Mus musculus 
Oncogenic levels of Myc expression sensitize cells to multiple apoptotic stimuli and this protects long-lived organisms from cancer development. How cells discriminate physiological from supra-physiological levels of Myc is largely unknown. Here we show that induction of apoptosis by Myc in breast e...
ORGANISM(S): Homo sapiens 
Analysis of Retinoblastoma protein (Rb) (Hs.408528) dependent transcriptional changes following siRNA mediated ablation of the RET finger protein/ Tripartite protein (RFP/TRIM27) (Hs.440382). Common reference design, two biological replicates with two technical replicates each.
ORGANISM(S): Homo sapiens 
Analysis of Gene Regulation by Myc in the absence of HectH9
ORGANISM(S): Homo sapiens 
Oncogenic levels of Myc expression sensitize cells to multiple apoptotic stimuli and this protects long-lived organisms from cancer development. How cells discriminate physiological from supra-physiological levels of Myc is largely unknown. Here we show that induction of apoptosis by Myc in breast e...
ORGANISM(S): Homo sapiens 
Primary murine keratinocytes were infected with Myc, MycV394D or control virus supernatants and treated with or without TGF beta 1 for 12 hours. MycV394D is a Myc mutant, which does not bind Miz-1 anymore but is still able to bind to E-box sequences (Mol Cell 10:509-521, 2002).
ORGANISM(S): Mus musculus 
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