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TranscriptomicsDiffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the remainder succumb to the disease. We proposed that this variability in natural history refle...
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-60 | biostudies-arrayexpress
TranscriptomicsSecreted and membrane-associated genes
Large-scale identification of secreted and membrane-associated gene products using DNA microarrays. This study is described more fully in Diehn M et al.(2000) Nat Genet 25:58-62
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-48 | biostudies-arrayexpress
TranscriptomicsDNA copy-number changes
Gene amplifications and deletions frequently contribute to tumorigenesis. Characterization of these DNA copy-number changes is important for both the basic understanding of cancer and its diagnosis. Comparative genomic hybridization (CGH) was developed to survey DNA copy-number variations across a w...
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-49 | biostudies-arrayexpress
TranscriptomicsTranscriptional Response of 0.1%YE-grown M. sedula cells to ferrous sulfate
(from abstract): Iron oxidation is a desirable trait of biomining microorganisms, although the mechanism is not well-understood in extreme thermoacidophiles. The complete genome sequence of the extremely thermoacidophilic archaeon Metallosphaera sedula DSM 5348 (2.2 Mb, ~2300 ORFs) provides insights...
ORGANISM(S): Metallosphaera sedula 
2008-05-02 | E-GEOD-11296 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of diffuse large B-cell lymphoma identifying different subtypes
Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the remainder succumb to the disease. We proposed that this variability in natural history refle...
ORGANISM(S): Homo sapiens 
2005-06-28 | E-SMDB-183 | biostudies-arrayexpress
TranscriptomicsDifferential expression of genes in the WT and hupB KO strain of Mycobacterium tuberculosis H37Rv upon iron limitation
HupB is a 28 kDa in Mycobacterium tuberculosis that is co-expressed with the siderophores mycobactin and carboxymycobactin upon iron limitation. High levels of all the three components are seen in low iron (LI; 0.02 M-BM-5g Fe / mL) organisms, with negligible expression in high iron organisms (HI; 8...
ORGANISM(S): Mycobacterium tuberculosis 
2014-03-18 | E-GEOD-53254 | biostudies-arrayexpress
TranscriptomicsIdentifying mRNA targets of microRNA in clear cell renal cell carcinoma
A bioinformatic approach to identify targets of microRNA in cancer. Keywords: Patient sample study Samples GSM413237-GSM413270: Total RNA from 17 RCC tumors and 17 corresponding non-tumor samples was hybridized against a common reference RNA (Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits...
ORGANISM(S): Homo sapiens 
2011-02-28 | E-GEOD-16441 | biostudies-arrayexpress
GenomicsEstablishment of regions of genomic activity during the Drosophila maternal-to-zygotic transition
A conspicuous feature of early animal development is the lack of transcription from the embryonic genome, and it typically takes several hours to several days (depending on the species) until widespread transcription of the embryonic genome begins. Although this transition is ubiquitous, relatively ...
ORGANISM(S): Drosophila melanogaster 
2014-10-16 | E-GEOD-58935 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of Drosophila melanogaster transcription factors BCD, HB, KR, KNI, GT, CAD, HKB, TLL, D, FTZ, HRY, PRD, RUN, SLP1, DA, DL, MAD, MED, SHN, SNA, TWI, TFIIB and RNA polII
ChIP-chip was performed using chromatin isolated from formaldehyde crosslinked, staged embryos, and affinity purified antibodies against 21 transcription factors (including: BCD, HB, KR, KNI, GT, CAD, HKB, TLL, D, FTZ, HRY, PRD, RUN, SLP1, DA, DL, MAD, MED, SHN, SNA, TWI) that belong to 11 DNA bind...
ORGANISM(S): Drosophila melanogaster 
2009-07-27 | E-TABM-736 | biostudies-arrayexpress
TranscriptomicsmRNAs translated at eIF4F
Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray. Although most eukaryotic mRNAs need a functional cap binding complex eIF4F for efficient 5' end-dependent scanning to initiate translation, picornaviral, hepatitis C vi...
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-62 | biostudies-arrayexpress
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