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TranscriptomicsTranscription profiling of mRNAs that remained associated with polysomes isolated from human cells after infection with poliovirus
Although most eukaryotic mRNAs need a functional cap binding complex eIF4F for efficient 5' end- dependent scanning to initiate translation, picornaviral, hepatitis C viral, and a few cellular RNAs have been shown to be translated by internal ribosome entry, a mechanism that can operate in the prese...
ORGANISM(S): Homo sapiens 
2005-06-24 | E-SMDB-59 | biostudies-arrayexpress
TranscriptomicsIdentifying mRNA targets of microRNA in clear cell renal cell carcinoma
A bioinformatic approach to identify targets of microRNA in cancer. Keywords: Patient sample study Samples GSM413237-GSM413270: Total RNA from 17 RCC tumors and 17 corresponding non-tumor samples was hybridized against a common reference RNA (Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits...
ORGANISM(S): Homo sapiens 
2011-02-28 | E-GEOD-16441 | biostudies-arrayexpress
GenomicsEstablishment of regions of genomic activity during the Drosophila maternal-to-zygotic transition
A conspicuous feature of early animal development is the lack of transcription from the embryonic genome, and it typically takes several hours to several days (depending on the species) until widespread transcription of the embryonic genome begins. Although this transition is ubiquitous, relatively ...
ORGANISM(S): Drosophila melanogaster 
2014-10-16 | E-GEOD-58935 | biostudies-arrayexpress
TranscriptomicsNon-canonical compensation of zygotic X transcription in Drosophila melanogaster development revealed through single embryo RNA-Seq
We sequenced mRNA from 24 single D. melanogaster embryos (12 male and 12 female) taken from 8 early embryonic timepoints to generate the first sex specific timecourse of gene expression in early Drosophila development Examination of mRNA levels in individual male and female embryos at 8 timepoints b...
ORGANISM(S): Drosophila melanogaster 
2011-02-07 | E-GEOD-25180 | biostudies-arrayexpress
TranscriptomicsIdentification of direct T-box target genes in the developing zebrafish mesoderm
The zebrafish genes spadetail (spt) and no tail (ntl) encode T-box transcription factors that are important for early mesoderm development. Although much has been done to characterize these genes, the identity and location of target regulatory elements remain largely unknown. Here, we survey the gen...
ORGANISM(S): Danio rerio 
2010-05-19 | E-GEOD-12857 | biostudies-arrayexpress
GenomicsZelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition
The earliest stages of development in most metazoans are driven by maternally deposited proteins and mRNAs, with widespread transcriptional activation of the zygotic genome occurring hours after fertilization, at a period known as the maternal-to-zygotic transition (MZT). In Drosophila, the MZT is p...
ORGANISM(S): Drosophila melanogaster 
2011-07-18 | E-GEOD-30757 | biostudies-arrayexpress
GenomicsDual Functions of TAF7L in Adipocyte Differentiation
The diverse transcriptional mechanisms governing cellular differentiation and development of mammalian tissue remains poorly understood. Here we report that TAF7L, a paralogue of TFIID subunit TAF7, is enriched in adipocytes and mouse white fat tissue (WAT). Depletion of TAF7L reduced adipocyte-spec...
ORGANISM(S): Mus musculus 
2013-01-07 | E-GEOD-41937 | biostudies-arrayexpress
TranscriptomicsDCC binding and function (ChIP-chip: SDC-3, MIX-1, DPY-27, Mock)
In many species, a dosage compensation complex (DCC) is targeted to X chromosomes of one sex to equalize levels of X gene products between males (1X) and females (2X). Here we identify cis-acting regulatory elements that target the C. elegans X chromosome for repression by the DCC. The DCC binds t...
ORGANISM(S): Caenorhabditis elegans 
2010-05-22 | E-GEOD-14650 | biostudies-arrayexpress
TranscriptomicsWhole-exome sequencing (WES) to assess genomic concordance between an adenoma/adenocarcinoma colonoid culture 14-881 and the source patient tissue
A patient-derived epithelium-only colon rectal organoid, also referred to as a colonoid, was generated from an adenoma (associated with a resection surgery of an invasive moderately differentiated colorectal adenocarcinoma) as part of the development of an on-going organoid biobank at the Michigan M...
ORGANISM(S): Homo sapiens 
2020-12-22 | E-MTAB-9936 | biostudies-arrayexpress
UnknownGenome-wide association study identifies multiple risk loci for renal cell carcinoma.
Not available
S-EPMC5472706 | biostudies-literature
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