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TranscriptomicsTargeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects
Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML) is an autosomal dominant disease of the hematopoietic system, which is caused by heterozygous mutations in RUNX1. FPD/AML patients have a bleeding disorder characterized by thrombocytopenia with reduced platelet numb...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-54295 | biostudies-arrayexpress
TranscriptomicsCD47 Inhibits Self-renewal and Reprogramming by Regulating c-Myc and Other Stem Cell Transcription Factors
Signaling through the thrombospondin-1 receptor CD47 broadly limits cell and tissue survival of stress, but the molecular mechanisms are incompletely understood. We now show that loss of CD47 permits sustained proliferation of primary murine endothelial cells and enables these cells to spontaneously...
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-43133 | biostudies-arrayexpress
TranscriptomicsTCF1 is required for the differentiation of T follicular helper (TFH) cells during viral infections
TFH and Th1 cells generated after viral or intracellular bacterial infections are critical for the control of infections and the development of immunological memories. However, the mechanisms that govern the choice of activated CD4 T cells to the two alternative fates remain unclear. Here, we found ...
ORGANISM(S): Mus musculus 
2015-09-18 | E-GEOD-65660 | biostudies-arrayexpress
UnknownAn integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer's disease.
Not available
S-EPMC4731966 | biostudies-literature
UnknownCandesartan could ameliorate the COVID-19 cytokine storm.
Not available
S-EPMC7439834 | biostudies-literature
UnknownIsolation and characterization of a metastatic hybrid cell line generated by ER negative and ER positive breast cancer cells in mouse bone marrow
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-27515 | biostudies-other
UnknownIdentification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study.
Not available
S-EPMC3595425 | biostudies-literature
TranscriptomicsTruncating mutations of STAG2 define a molecular subgroup of aneuploid bladder cancers with poor prognosis.
Aneuploidy is among the most common hallmarks of cancer, yet the underlying genetic mechanisms are still poorly defined. We have recently identified STAG2 as a gene that is mutated in human cancer and whose inactivation leads directly to chromosomal instability and aneuploidy. However, no single tum...
ORGANISM(S): Homo sapiens 
2013-06-30 | E-GEOD-41581 | biostudies-arrayexpress
TranscriptomicsRole of REG 1 in Entamoeba histolytica colitis
Differential expression was used to access gene differences after Entamoeba histolytica infection. Entamoeba histolytica is an important diarrheal pathogen worldwide, and induces apoptosis of the intestinal epithelium as part of its disease process. Regenerating (REG) 1 protein is anti-apoptotic. ...
ORGANISM(S): Homo sapiens 
2011-05-24 | E-GEOD-23750 | biostudies-arrayexpress
TranscriptomicsCell transcriptional state alters genomic patterns of DNA double-strand break repair in human astrocytes
The misrepair of DNA double-strand breaks in close spatial proximity within the nucleus can result in chromosomal rearrangements that are important in the pathogenesis of hematopoietic and solid malignancies. It is unknown why certain epigenetic states, such as those found in stem or progenitor cel...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-45994 | biostudies-arrayexpress
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