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MetabolomicsJ-Resolved 1H NMR 1D-Projections for Large-Scale Metabolic Phenotyping Studies: Application to Blood Plasma Analysis
1H nuclear magnetic resonance (NMR) spectroscopy-based metabolic phenotyping is now widely used for large-scale epidemiological applications. To minimize signal overlap present in 1D 1H NMR spectra, we have investigated the use of 2D J-resolved (JRES) 1H NMR spectroscopy for large-scale phenotyping ...
2018-07-23 | MTBLS540 | MetaboLights
MetabolomicsTreatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC-MS metabolomics
Introduction: Obestatin is a controversial gastrointestinal peptide purported to have metabolic actions. Objectives: This study investigated whether treatment with a stable obestatin analogue (PEG-OB(Cys10, Cys13) changed plasma metabolite levels firstly in lean and subsequently in diet-induced obes...
2017-07-25 | MTBLS334 | MetaboLights
UnknownBiochemical analysis of the interactions of IQGAP1 C-terminal domain with CDC42.
Not available
S-EPMC3312201 | biostudies-literature
UnknownReactivity of canonical bacterial cytochrome <i>c</i> peroxidases: insights into the electronic structure of compound I.
Not available
S-EPMC11892367 | biostudies-literature
UnknownVisualizing the replication cycle of bunyamwera orthobunyavirus expressing fluorescent protein-tagged Gc glycoprotein.
Not available
S-EPMC2919021 | biostudies-literature
ProteomicsIdentification of neoantigens in oesophageal adenocarcinoma
We present data from tissues of seven oesophageal adenocarcinomas of CD4 and CD8 T cell epitopes eluted from the cell surface using mass spectrometry (immunopeptidomics) of presented HLA bound peptides.This dataset forms part of the publication:Nicholas, B., Bailey, A., McCann, K.J., Wood, O., Walke...
ORGANISM(S): Homo sapiens (Human) 
2022-09-27 | PXD031108 | Pride
Human Oesophageal adenocarcinoma Immunopeptidome Hla 
ProteomicsLoss of H3K9 tri-methylation alters mitotic chromosome compaction and transcription factor retention during mitosis
Recent studies have shown that repressive chromatin machinery, including DNA methyltransferases (DNMTs) and Polycomb Repressor Complexes (PRCs), bind to chromosomes throughout mitosis and their depletion results in increased chromosome size. Enzymes that catalyse H3K9 methylation, such as Suv39h1, S...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-12 | PXD030771 | Pride
Chromatin  mitotic chromosomes  h3k9me3  suv39h1  suv39h2  ezh2  esrrb 
UnknownDo concerns about COVID-19 impair sustained attention?
Not available
S-EPMC8159070 | biostudies-literature
UnknownEpigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study.
Not available
S-EPMC4724884 | biostudies-literature
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
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