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Elongation Factor P is important for sporulation initiation
Cellular senescence is characterized by a permanent growth arrest and is associated with tissue aging and cancer. Senescent cells secrete a number of different cytokines referred to as the senescence-associated secretory phenotype (SASP), which impacts the surrounding tissue and immune response. Her...
2024-08-14 | MTBLS10690 | MetaboLights
Testing the consequences of the absence of the transcript elongation factor TFIIS on the transcriptome in Arabidopsis. Keywords: Comparison of mutant and wildtype Four replicate RNA extractions were performed of each genotype using independent pools of plants. Samples were hybridized in two dye-swap...
ORGANISM(S): Arabidopsis thaliana 
Here we report our observations that have led us to propose that the transcription elongation factor NusA promotes a novel class of transcription-coupled repair (TCR) in addition to its previously proposed role in recruiting translesion synthesis (TLS) DNA polymerases to gaps encountered during tran...
ORGANISM(S): Escherichia coli 
Stalling of ribosomes due to consecutive proline motifs during polypeptide synthesis is a challenge faced by organisms across all kingdoms. To overcome this, bacteria employ translation elongation factor P (EF-P), while archaea and eukaryotes rely on a/eIF5A. Typically, these elongation factors beco...
ORGANISM(S): Weeksella virosa Rhodomicrobium vannielii ATCC 17100 Escherichia coli 
2024-04-08 | PXD044929 | Pride
Protein translation factors play crucial roles in a variety of stress responses. Here, we show that the eukaryotic elongation factor 1Bdelta (eEF1Bdelta) changes its structure and function from a translation factor into a heat shock response transcription factor by alternative splicing. While eEF1Bd...
ORGANISM(S): Homo sapiens 
The Eleven-nineteen Lysine-rich Leukemia (ELL)-containing Super Elongation Complex (SEC) containing P-TEFb is a key regulator in the expression of HOX genes in Mixed Lineage Leukemia (MLL)-based leukemia. We have identified an SEC-like complex in Drosophila, as well as a distinct ELL-containing comp...
ORGANISM(S): Drosophila melanogaster 
Bacterial translational elongation factor P (EF-P) is required during translation of proteins containing consecutive proline motifs. Several transcription and translational regulators contain polyproline motifs and therefore, EF-P might also affect levels of proteins that do not contain polyproline ...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2020-04-06 | PXD014742 | Pride
Transcription by RNA polymerase II (Pol II) is a tightly regulated process in eukaryotes. A recent study revealed that the trimethylation of histone H3 at lysine 4 (H3K4me3) activates gene expression by promoting Pol II pause-release and transcription elongation rather than transcription initiation....
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-01-27 | PXD061239 | Pride
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