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ProteomicsBrief suppression of SUMOylation in embryonic stem cells generates embryo-like structures
Recent advances in synthetic mammalian embryo models have opened new avenues to understand the complex events controlling lineage specification and morphogenetic processes occurring during peri-implantation and early organogenesis. Two main strategies have been developed to build embryo-like structu...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-13 | PXD031548 | Pride
Embryo-like structures Repression Sumo Endogenous Stem cells Spheroids Chromatin 
GenomicsRetinoic acid induces human gastruloids with posterior embryo-like structures
Retinoic acid induces human gastruloids with posterior embryo-like structures
PRJNA859692 | ENA
GenomicsHypoSUMOylation in embryonic stem cells generate head-trunk embryo-like structures [scRNAseq]
HypoSUMOylation in embryonic stem cells generate head-trunk embryo-like structures [scRNAseq]
PRJNA749070 | ENA
GenomicsHypoSUMOylation in embryonic stem cells generate head-trunk embryo-like structures [ChIP-seq]
HypoSUMOylation in embryonic stem cells generate head-trunk embryo-like structures [ChIP-seq]
PRJNA813445 | ENA
TranscriptomicsRetinoic acid induces human gastruloids with posterior embryo-like structures
Gastruloids are a powerful in vitro model of early human development. However, although elongated and composed of all three germ layers, human gastruloids do not morphologically resemble post-implantation human embryos. Here we show that an early pulse of retinoic acid (RA), together with later Matr...
ORGANISM(S): Homo sapiens 
2024-06-20 | GSE208369 | GEO
UnknownTransient suppression of SUMOylation in embryonic stem cells generates embryo-like structures.
Not available
S-EPMC10157296 | biostudies-literature
UnknownRetinoic acid induces human gastruloids with posterior embryo-like structures.
Not available
S-EPMC11469962 | biostudies-literature
TranscriptomicsHypoSUMOylation in embryonic stem cells generate head-trunk embryo-like structures [scRNAseq]
Numerous models of synthetic embryos have recently been established to simulate mammalian development. Two main strategies have been developed to build mouse or human embryo-like structures (ELS): by assembling embryonic and extraembryonic stem cells or by challenging embryonic stem cells (ESCs) wit...
ORGANISM(S): Mus musculus 
2023-03-17 | GSE180679 | GEO
GenomicsHypoSUMOylation in embryonic stem cells generate head-trunk embryo-like structures [ChIP-seq]
Numerous models of synthetic embryos have recently been established to simulate mammalian development. Two main strategies have been developed to build mouse or human embryo-like structures (ELS): by assembling embryonic and extraembryonic stem cells or by challenging embryonic stem cells (ESCs) wit...
ORGANISM(S): Mus musculus 
2023-03-17 | GSE198025 | GEO
UnknownImplantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells.
Not available
S-EPMC6353907 | biostudies-literature
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