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TranscriptomicsShort-term (12h) ATRA treatment of embryoid bodies.
We used microarrays to detail the global programme of gene expression in embryonic stem cells, early differentiated embrioid bodies and effect of short-term ATRA treatment. Expression data from undifferentiated mouse embryonic stem cells (D3), four-day old aggregated embrioid bodies and 12h atRA or ...
ORGANISM(S): Mus musculus 
2010-07-16 | E-GEOD-20919 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human embryonic stem (ES) cells. Undifferentiated cells of different passage numbers (p19 and p128) were vs cells differentiated in hanging drops for 5 days (d5 embryoid bodies) or expanded on gelatin coated dishes for a further 9 days (d14 embryoid bodies)
Undifferentiated cells of different passage numbers (p19 and p128) were compared to cells differentiated in hanging drops for 5 days (d5 embryoid bodies) or expanded on gelatin coated dishes for a further 9 days (d14 embryoid bodies).
ORGANISM(S): Homo sapiens 
2005-08-31 | E-MEXP-303 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryoid bodies with HOXB4 induced or not induced to identify its target genes
To unravel the molecular mechanism by which HOXB4 promotes the expansion of early hematopoietic progenitors within differentiating ES cells, we analzed the gene expression profiles of embryoid bodies (EBs) in which transcription of HOXB4 had been induced or not induced. A substantial number of the i...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9044 | biostudies-arrayexpress
TranscriptomicsExpression data from Mst knockout embryoid bodies and wild type embryoid bodies
Mst1/Mst2 are central components of Hippo pathway. We examined the role of Mst1/Mst2 in ES cell differentiation. In this data set, we include expression data from day 4 and day 8 Mst1/Mst2 knockout ES cell formed embryoid bodies and wild type embryoid body controls. total 4 samples.
ORGANISM(S): Mus musculus 
2014-01-02 | E-GEOD-50219 | biostudies-arrayexpress
TranscriptomicsGeminin represses mesendoderm cell fate acquisition in embryoid bodies
Geminin is a small nucleoprotein that neuralizes ectoderm in the Xenopus embryo. Geminin promotes neural fate acquisition of mouse embryonic stem cells: Geminin knockdown during neural fate acquisition decreased expression of neural precursor cell markers (Pax6, Sox1), while increasing expression of...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-39676 | biostudies-arrayexpress
TranscriptomicsRelocalization of retinoic acid receptors from non-canonical to canonical spaced binding elements during embryoid body differentiation
Retinoic Acid Receptors (RARs) bind RA-response elements in regulatory regions of their target genes. While canonical RAREs comprise direct repeats of the consensus 5’-RGKTCA-3’ sequence separated by 1, 2 or 5 nucleotides (DR1, DR2, DR5), we show that shortly after RA treatement of mouse embryoid bo...
ORGANISM(S): Mus musculus 
2012-06-15 | E-GEOD-35599 | biostudies-arrayexpress
TranscriptomicsExpression data from wild type and globally hypomethylated mouse embryonic stem cells (ESCs) during their differentiation as embyroid bodies
To analyze the role of DNA methylation during differentiation, we performed genome-wide expression analysis of undifferentiated wild type, dnmt1-/- and triple knock out (TKO; dnmt1-/-, dnmt3a-/-, dnmt3b-/-) ESCs as well as respective embryoid bodies (EBs) at two stages of differentiation We generate...
ORGANISM(S): Mus musculus 
2013-02-05 | E-GEOD-36679 | biostudies-arrayexpress
TranscriptomicsImprinted expression is different in visceral yolk sac and cystic embryoid body endoderm
Genomic imprinting is an epigenetic phenomenon resulting in parent-of-origin mono-allelic expression of a small subset of mammalian genes. Imprinted genes have been categorized into two groups: multi lineage (ML) imprinted genes that can show imprinted expression in both embryonic and extra-embryoni...
ORGANISM(S): Mus musculus 
2015-07-22 | E-GEOD-56276 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of Homo sapiens differentiated primordial germ cell-like cell derived from embryoid bodies
We sequenced embryoid bodies at various time points following induction of pre-mesendoderm cells (PreME) towards primordial germ cell-like cell (PGCLC) fate
ORGANISM(S): Homo sapiens 
2023-05-05 | E-MTAB-11283 | biostudies-arrayexpress
TranscriptomicsExpression data from human induced pluripotent stem cell-derived teratomas and embryoid bodies
The tumorigenicity of human pluripotent stem cells (hPSCs) is a major safety concern for their application in regenerative medicine. Here we identify the tight-junction protein Claudin-6 as a specific cell surface marker of hPSCs that can be used to selectively remove Claudin-6-positive cells from m...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-38088 | biostudies-arrayexpress
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