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MetabolomicsMetabolite Correlation Networks Reveal Complex Phenotypes of Adaptation-Driving Mutations

Living organisms are organized into hierarchical levels of increasing complexity. As mutational effects propagate through these levels, multiple phenotypes are produced. However, identifying which phenotypes influence fitness and drive selection remains a key challenge in understanding genotype-p...

2026-08-10 | MTBLS14569 | MetaboLights
GenomicsClustering of Surrogates of Cardiovascular Risk Factors Results in Emergent Phenotypes in Endothelial Cells
Clustering of Surrogates of Cardiovascular Risk Factors Results in Emergent Phenotypes in Endothelial Cells
PRJNA753527 | ENA
TranscriptomicsClustering of Surrogates of Cardiovascular Risk Factors Results in Emergent Phenotypes in Endothelial Cells
Global gene expression of human coronary artery endothelial cells (HCAEC) submitted surrogates of cardiovascular risk factors Based on the analysis of global gene expression in human coronary artery endothelial cells (HCAEC), we identified gene pathways and inferred cellular processes that are modul...
ORGANISM(S): Homo sapiens 
2022-02-02 | GSE181822 | GEO
GenomicsMorphological profiling of chondrogencially-induced multipotent stromal cell aggregates reveals emergent morphological phenotypes predictive of functional capacity
Morphological profiling of chondrogencially-induced multipotent stromal cell aggregates reveals emergent morphological phenotypes predictive of functional capacity
PRJNA434464 | ENA
UnknownUncovering emergent phenotypes in endothelial cells by clustering of surrogates of cardiovascular risk factors.
Not available
S-EPMC8789842 | biostudies-literature
UnknownFunctional Profiling of Chondrogenically Induced Multipotent Stromal Cell Aggregates Reveals Transcriptomic and Emergent Morphological Phenotypes Predictive of Differentiation Capacity.
Not available
S-EPMC6127231 | biostudies-literature
TranscriptomicsInduction of a hemogenic program in mouse fibroblasts
Definitive hematopoiesis emerges during embryogenesis via an endothelial-to-hematopoietic transition. We attempted to induce this process in mouse fibroblasts by screening a panel of factors for hemogenic activity. We identified a combination of four transcription factors, Gata2, Gfi1b, cFos, and Et...
ORGANISM(S): Mus musculus 
2013-06-13 | E-GEOD-47497 | biostudies-arrayexpress
UnknownHigh-Dimensional Phenotyping Identifies Age-Emergent Cells in Human Mammary Epithelia.
Not available
S-EPMC5946804 | biostudies-literature
TranscriptomicsTranscription profiling of mouse primary cultures from mouse cornea vs those of the adult and 10-day postnatal mouse cornea to elucidate biological processes underlying the keratocyte, fibroblast, and myofibroblast phenotypes of corneal stromal cells
To elucidate biological processes underlying the keratocyte, fibroblast, and myofibroblast phenotypes of corneal stromal cells, the gene expression patterns of these primary cultures from mouse cornea were compared with those of the adult and 10-day postnatal mouse cornea.
ORGANISM(S): Mus musculus 
2007-10-31 | E-GEOD-1867 | biostudies-arrayexpress
ProteomicsEnsemble and iterative engineering for maximal bioconversion to the blue pigment, Indigoidine from non-canonical sustainable carbon sources.
While many heterologous molecules can be produced at trace concentrations via microbial bioconversion processes, maximizing their titers, rates, and yields from lignin-derived carbon streams remains challenging. Strong growth coupling can not only increase titers and yields but also shift the produc...
ORGANISM(S): Pseudomonas putida KT2440 
2024-02-29 | PXD040697 | Pride
Emergent cell phenotypes Lignin Growth coupling Recombineering Proteomics analysis Ale Bioproduction Heterologous pathway Crispr Indigoidine Genome scale metabolic models Strain engineering 
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