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TranscriptomicsRNA-seq of human NSCL cell lines with induced fusion genes; ALK-EML4-V1, ALK-EML4-V3, ALK-TFG, ALK-KIF5B
To characterize the effects of common ALK fusion genes, we performed a comprehensive RNA-Seq analysis of NL20 cells induced with ALK-EML4-V1, ALK-EML4-V3, ALK-TFG, ALK-KIF5B, using Doxycycline
ORGANISM(S): Homo sapiens 
2022-12-18 | E-MTAB-11304 | biostudies-arrayexpress
GenomicsRNA-seq of human NSCL cell lines with induced fusion genes ALK-EML4-V1, ALK-EML4-V3, ALK-TFG, ALK-KIF5B
RNA-seq of human NSCL cell lines with induced fusion genes ALK-EML4-V1, ALK-EML4-V3, ALK-TFG, ALK-KIF5B
PRJEB50074 | ENA
ProteomicsThe EML4-ALK Interactome in Lung Cancer
We experimentally generated an ALK interactome combining quantitative tyrosine phosphoproteomics and protein complex annotation using affinity purification coupled with mass spectrometry and further investigated downstream ALK signaling using quantitative tyrosine phosphoproteomics.
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD004935 | Pride
Human Eml4-alk Interactome Lung cancer 
GenomicsExpression data from EML4-ALK overexpression in HEK293 cell line and EML4-ALK knockdown in H2228 lung cancer cell line.
Expression data from EML4-ALK overexpression in HEK293 cell line and EML4-ALK knockdown in H2228 lung cancer cell line.
PRJNA731500 | ENA
GenomicsTranscription analysis of CBX3::ALK Fusion and EML4-ALK Fusion that drives ALK Activation
Transcription analysis of CBX3::ALK Fusion and EML4-ALK Fusion that drives ALK Activation
PRJNA1371974 | ENA
GenomicsEML4-ALK variant-specific genetic interactions shape lung tumorigenesis
EML4-ALK variant-specific genetic interactions shape lung tumorigenesis
PRJNA1291647 | ENA
GenomicsEML4-ALK variant-specific genetic interactions shape lung tumorigenesis
EML4-ALK variant-specific genetic interactions shape lung tumorigenesis
PRJNA1284293 | ENA
TranscriptomicsExpression data from EML4-ALK overexpression in HEK293 cell line and EML4-ALK knockdown in H2228 lung cancer cell line.
We demonstrate that EML4-ALK siRNAs significantly reduced cell viability in EML4-ALK postive lung cancer cell lines,while overexpression of EML4-ALK increased cell viability in HEK293 cells in vitro. The aim of this study was to analyze the EML4-ALK regulated gene expression in lung cancer.
ORGANISM(S): Homo sapiens 
2021-05-20 | GSE174772 | GEO
TranscriptomicsEML4-ALK variant-specific genetic interactions shape lung tumorigenesis
Oncogenic fusions of EML4 and ALK occur in ~5% of lung adenocarcinomas. EML4-ALK variants have distinct breakpoints within EML4, but the functional differences among these variants remain poorly understood. Here we use CRISPR/Cas9 somatic genome editing to generate autochthonous mouse models of the ...
ORGANISM(S): Mus musculus 
2025-08-12 | GSE302650 | GEO
GenomicsEML4-ALK variant-specific genetic interactions shape lung tumorigenesis
Oncogenic fusions of EML4 and ALK occur in ~5% of lung adenocarcinomas. EML4- ALK variants have distinct breakpoints within EML4, but the functional differences among these variants remain poorly understood. Here we use CRISPR/Cas9 somatic genome editing to generate autochthonous mouse models of the...
ORGANISM(S): Mus musculus 
2025-08-06 | GSE301214 | GEO
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