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The model describes the mammalian heat shock response network using four dynamical variables: temperature, misfolded proteins (MFP), HSP mRNA, and heat shock proteins (HSP). Heat stress increases protein denaturation, generating MFPs that compete with HSF1 for binding to HSP chaperones. This sequest...
2026-09-02 | MODEL2608180003 | BioModels
Cigarette smoke causes diseases such as cardiovascular disorders. Heating tobacco, instead of burning, reduces consistently the amount of toxic compounds and may exert a reduced impact on cardiovascular health compared to cigarettes. Aqueous extract from the aerosol of a potential modified risk toba...
ORGANISM(S): Homo sapiens 
BTG1 is recurrently mutated in the MCD/C5 subgroup of diffuse large B cell lymphoma (DLBCL), but the functions of this gene in lymphomagenesis have never been investigated so far. Here we provide evidence that Btg1 knock out accelerates the development of a lethal lymphoproliferative disease driven ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-10 | MSV000089045 | MassIVE
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