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TranscriptomicsGenomic profiling of 19 renal cell carcinoma samples from patients with end-stage renal disease
In this study, 19 tumor samples from patients with renal cell carcinoma (RCC)-end-stage renal disease (ESRD) were analyzed by array comparative genomic hybridization (array CGH) using the Agilent Whole Human Genome 4× Array. 19 cystic disease samples from patients with RCC-ESRD
ORGANISM(S): Homo sapiens 
2012-04-01 | E-GEOD-33117 | biostudies-arrayexpress
MetabolomicsA Novel Metabolic Signature To Predict the Requirement of Dialysis or Renal Transplantation in Patients with Chronic Kidney Disease
Identification of chronic kidney disease patients at risk of progressing to end-stage renal disease (ESRD) is essential for treatment decision-making and clinical trial design. Here, we explored whether proton nuclear magnetic resonance (NMR) spectroscopy of blood plasma improves the currently best ...
2019-07-26 | MTBLS798 | MetaboLights
MetabolomicsAberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

OBJECTIVE: Patients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced from studies in animals. The aim of the study is to characterise relationships between the intestinal microbiome composition, uraemic toxins and rena...

2020-10-20 | MTBLS700 | MetaboLights
MetabolomicsImpact of Diabetic Stress Conditions on Renal Cell Metabolome
Diabetic kidney disease is a major complication in diabetes mellitus, and the most common reason for end-stage renal disease. Patients suffering from diabetes mellitus encounter glomerular damage by basement membrane thickening, and develop albuminuria. Subsequently, albuminuria can deteriorate the ...
2019-10-08 | MTBLS1093 | MetaboLights
MetabolomicsMetabolomic Profiling of Renal Cyst Fluid in Advanced ADPKD: Insights from Dialysis and Transplantation Cohorts

Background: Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder characterized by progressive renal cyst formation, often leading to end-stage kidney disease (ESKD). While urinary metabolomics in ADPKD has been extensively studied, the composition of renal cyst fluid, par...

2025-07-07 | MTBLS12372 | MetaboLights
TranscriptomicsTranscription profiling of human stable end-stage renal disease patients reveals nocturnal hemodialysis improves erythropoietin responsiveness
Nocturnal home hemodialysis (NHD) [5 – 6 times a week, 6-8 hours per session] augments uremia clearance and is associated with an increase in hemoglobin level. We have used microarray to have a global image of the changes at the gene expression. Experiment Overall Design: Sixteen stable end-sta...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-11227 | biostudies-arrayexpress
TranscriptomicsImmune transcriptional profiling in end-stage renal disease
Purified leukocyte subsets in patients with end-stage renal disease were compared transcriptionally with those from healthy controls
ORGANISM(S): Homo sapiens 
2018-01-11 | E-MTAB-2413 | biostudies-arrayexpress
TranscriptomicsExpression data from uremic patients (end stage renal failure) and 20 healthy controls
Renal failure is characterized by important biological changes resulting in profound pleomorphic physiological effects termed “uremia”, whose molecular causation is not well understood. The data was used to study gene expression changes in uremia using whole genome microarray analysis of peripheral ...
ORGANISM(S): Homo sapiens 
2012-04-11 | E-GEOD-37171 | biostudies-arrayexpress
MetabolomicsAltered fecal microbial and metabolic profiles reveal potential mechanisms underlying anemia in patients with chronic renal failure

The gut microbiomes communicate with kidney and may play a crucial role in the development of anemia in patients with chronic renal failure (CRF). However, the alterations in microbiota and their association with functional metabolites remain unclear. We performed metagenomics and untargeted meta...

2025-06-13 | MTBLS6334 | MetaboLights
MetabolomicsAltered fecal microbial and metabolic profiles reveal potential mechanisms underlying anemia in patients with chronic renal failure

The gut microbiomes communicate with kidney and may play a crucial role in the development of anemia in patients with chronic renal failure (CRF). However, the alterations in microbiota and their association with functional metabolites remain unclear. We performed metagenomics and untargeted meta...

2025-06-13 | MTBLS12576 | MetaboLights
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