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GenomicsCommensal microbe-derived butyrate epigenetically induces colonic regulatory T cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-11-20 | E-GEOD-49655 | biostudies-arrayexpress
TranscriptomicsExpression data from CD4+ NaM-CM-/ve T cells under Treg-inducing condition in the presence or absence of butyrate
Commensal bacteria shapes gut immune system. Colonization bacteria increase the frequency of regulatory T cells, however, the molecular mechanisms has not yet been unknown. To reveal the mechanism, we isolated NaM-CM-/ve CD4+ T cells from spleen of C57BL/6 mice and cultured the cells under Treg-indu...
ORGANISM(S): Mus musculus 
2013-11-20 | E-GEOD-49619 | biostudies-arrayexpress
GenomicsGenome-wide measurement of acetylated histone H3 in naïve cells under Treg-inducing conditon
To investigate the molecular mechanism how butyrate promoter differentiation of naïve T cells into regulatory T cells Examination of acetylated histone H3 during the differentiation of regulatory T cells in the presence or absence of butyrate
ORGANISM(S): Mus musculus 
2013-11-20 | E-GEOD-49653 | biostudies-arrayexpress
GenomicsGenome-wide measuement of methylated cytosin in regulatory T cells (Treg) and conventional T cells (Tconv) depleted with Uhrf1
To investigate the molecular mechanism how Uhrf1 regulate gene expression and cell cycle progression in Treg, we precipitated methylated DNA using recombinant MBD1 followed by genome-wide analysis of methylated gene loci by next generation sequencer Examination of methylated DNA in Treg and Tconv i...
ORGANISM(S): Mus musculus 
2014-04-07 | E-GEOD-56543 | biostudies-arrayexpress
TranscriptomicsExpression data from CD4+ T cells of germ free mice, SPF IQI mice and SPF C57BL/6 mice depletd with Uhrf1 (by Cd4Cre-Uhrf1flox/flox)
Commensal bacteria shapes gut immune system. Colonization bacteria increase the frequency of regulatory T cells, however, the molecular mechanisms has not yet been unknown. To reveal the mechanism, we isolated Treg cells and Non-Treg cells and performed the global expression analysis. Colonic lamina...
ORGANISM(S): Mus musculus 
2014-04-07 | E-GEOD-56542 | biostudies-arrayexpress
GenomicsRING1B binding in the 11 dpc embryonic tissues
We report the distribution of RING1B (one of Polycomb group factors) within the genome of mouse embryonic tissues. We prepared the chromatin from 11 dpc embryonic forebrain, midbrain, and forelimb buds and made chromatin precipitation with antibody against RING1B (mouse monoclonal antibody). High-th...
ORGANISM(S): Mus musculus 
2014-01-14 | E-GEOD-48464 | biostudies-arrayexpress
GenomicsEnhancer landscape of mouse developing midbrain at 11.5 dpc embryos
We report the distribution of histone H3K4me1 and H3K27ac within the genome of mouse embryonic midbrain. We prepared the chromatin from 11 dpc embryonic midbrain and made chromatin precipitation with antibody against H3K4me1 and H3K27ac (rabbit polyclonal antibody). High-throughput sequencing appli...
ORGANISM(S): Mus musculus 
2014-01-15 | E-GEOD-49652 | biostudies-arrayexpress
TranscriptomicsChIP-on-chip data from human ES cells-derived CD34+CD43+CD45low cells (hemogenic endothelium-like cells) overexpressing 3xFLAG-Sox17-ERT
Overexpression of transcription factor Sox17 in human ES cells-derived endothelial cells enhances expansion of hemogenic endothelium-like cells. Human ES cells were differentiated for 6 days in EBs, then CD34+CD43-CD45- endothelial cells were isolated, plated onto OP9 cells, and transduced with the ...
ORGANISM(S): Homo sapiens 
2012-12-14 | E-GEOD-37528 | biostudies-arrayexpress
GenomicsThe epigenetic regulator Uhrf1 facilitates functional expansion of colonic regulatory T cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-04-07 | E-GEOD-56544 | biostudies-arrayexpress
TranscriptomicsCritical role of SOX17 in the hematopoietic development from human embryonic stem cells
Human embryonic stem cells (hESCs) are a powerful tool for modeling regenerative therapy. To search for the genes that promote hematopoietic development from human pluripotent stem cell, we overexpressed a list of hematopoietic regulator genes in human pluripotent stem cell-derived CD34+CD43- endoth...
ORGANISM(S): Homo sapiens 
2012-12-14 | E-GEOD-38156 | biostudies-arrayexpress
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